Abstract
Mammalian reproduction is critically dependent on trophoblast cells, which ensure embryo implantation and placentation. Development of trophoblast cell lineages is a multi-step process and relies upon proper spatial and temporal gene expression, which is regulated by multiple transcription factors. However, most of the transcription factors that are implicated in trophoblast development regulate gene expression at a specific developmental stage or in a specific trophoblast subtype. In contrast, recent studies from our group and other laboratories indicate that conserved GATA family of transcription factors, GATA2 and GATA3, are important to regulate gene expression at multiple stages of trophoblast development. Furthermore, our conditional gene deletion studies revealed that functional redundancy of GATA2 and GATA3 ensures both self-renewal of trophoblast stem and progenitor cells and their differentiation to trophoblast cells of a matured placenta. Together these findings indicate that GATA2/GATA3 are the master orchestrators of gene expression in trophoblast cells and they fine tune gene regulatory network to establish distinct trophoblast cell types during placentation.
Citations
Sep 20, 2018·PLoS Biology·Caitlin E Dunn-FletcherLouis J Muglia
Jul 15, 2018·International Journal of Cancer. Journal International Du Cancer·Hsiang-Ju ChenHung-Cheng Lai
Oct 9, 2019·The Journal of Biological Chemistry·Jessica Milano-FosterSoumen Paul
Jan 16, 2020·PloS One·Naoko HiraharaTakafumi Suda
Mar 19, 2020·Molecular Human Reproduction·Xiaohe SunSongying Zhang
Apr 30, 2020·Journal of Cellular and Molecular Medicine·Guizhen DuYankai Xia
Jul 31, 2020·Human Reproduction Update·Shingo IoAnd Shigehito Yamada
May 3, 2019·Cellular and Molecular Life Sciences : CMLS·Martin KnöflerJoanna James
Jul 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Biswarup SahaSoumen Paul
Sep 11, 2019·Biology of Reproduction·Xiaorui LuanYanzhi Du
Jan 23, 2020·International Journal of Molecular Sciences·Andras SzilagyiNandor Gabor Than
Jan 31, 2021·International Journal of Molecular Sciences·Manabu OgoyamaToshihiro Takizawa
Nov 16, 2019·Placenta·C E FedorkaB A Ball
Jun 15, 2021·Human Reproduction Update·John D Aplin, Carolyn J P Jones
Aug 26, 2021·Nature Communications·Todd M EversonMariona Bustamante