GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage.

Nature Communications
Lauren A CallenderSian M Henson

Abstract

GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4+ T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune regulation, proliferation and maintenance in other T cell and non-T cell lineages. Here we show a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK. Activated AMPK increases expression of PPARG coactivator 1 alpha (PPARGC1A or PGC1α protein) at the level of transcription and GATA3 at the level of translation, while DNA damage enhances expression of nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2). PGC1α, GATA3 and NRF2 complex together with the ATR to promote mitochondrial biogenesis. These findings extend the pleotropic interactions of GATA3 and highlight the potential for GATA3-targeted cell manipulation for intervention in CD4+ T cell viability and function after DNA damage.

Associated Datasets

References

Jan 1, 1975·Mutation Research·J Timson
May 31, 1990·Nature·C B HarleyC W Greider
May 3, 2000·Clinical and Experimental Immunology·S Sakata-KanekoT Kita
Apr 3, 2001·Molecular and Cellular Biology·S Ranganath, K M Murphy
Jul 23, 2003·Immunity·Gabriela Hernández-HoyosJose Alberola-Ila
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brandon M SullivanLaurie H Glimcher
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sung-Yun PaiI-Cheng Ho
Apr 16, 2004·Immunity·Michael J TownsendLaurie H Glimcher
Jul 1, 2005·Molecular and Cellular Biology·Feng LiChi V Dang
Nov 8, 2005·Nature Immunology·Andrew M IntlekoferSteven L Reiner
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J KimI-Cheng Ho
Sep 18, 2007·Experimental Gerontology·Torsten Richter, Thomas von Zglinicki
Jul 29, 2008·Immunity & Ageing : I & a·Sven KochGraham Pawelec
Mar 12, 2009·Current Opinion in Lipidology·Carles Cantó, Johan Auwerx
Oct 9, 2009·The New England Journal of Medicine·Jan H J Hoeijmakers
Aug 11, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin D Cook, Jim Miller
Jul 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diletta Di MitriArne N Akbar
Aug 11, 2011·PLoS Computational Biology·Tilo BeyerJonathan A Lindquist
May 5, 2012·Current Opinion in Immunology·Sian M HensonArne N Akbar
Dec 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tzong-Shyuan TaiI-Cheng Ho
Aug 2, 2014·The Journal of Clinical Investigation·Sian M HensonArne N Akbar
May 11, 2016·Molecular and Cellular Biology·Min Sung JooSang Geon Kim
May 24, 2018·Nucleic Acids Research·Enis AfganDaniel Blankenberg
May 6, 2019·Nature Communications·Nicholas JonesCatherine A Thornton
Dec 4, 2019·Aging Cell·Lauren A CallenderSian M Henson
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N TominagaS Noguchi
Feb 11, 2020·Frontiers in Physiology·Dunja AksentijevićCraig A Lygate
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Sergio Rius-PérezSalvador Pérez
May 31, 2020·Metabolism: Clinical and Experimental·Min Jeong SonKwang-Hee Bae
Oct 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ji Hyun SimHang-Rae Kim

❮ Previous
Next ❯

Software Mentioned

Bowtie2 Galaxy
Imaris Image Analysis
TMRE
FlowJo
ZEN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioRxiv : the Preprint Server for Biology
Lauren A CallenderSian M Henson
The Journal of Experimental Medicine
Alla SkapenkoHendrik Schulze-Koops
Cellular & Molecular Immunology
I-Cheng Ho, Sung-Yun Pai
International Archives of Allergy and Immunology
Osamu KaminumaShoichiro Miyatake
© 2021 Meta ULC. All rights reserved