GATA4 inhibits cell differentiation and proliferation in pancreatic cancer

PloS One
Yan GongQiang Zeng

Abstract

Pancreatic ductal carcinoma (PDAC) is a common malignant tumor of the digestive system. GATA4 is one of the transcriptional regulatory factors, which regulates the development of endoderm-derived organs, including heart and gut. GATA4 may act as a putative tumor suppressor gene. However, the role of GATA4 in pancreatic carcinogenesis is not yet clarified. This study showed that GATA4 was highly expressed in pancreatic cancer tissues, and its expression level was positively related to the grade of pathological differentiation, suggesting that it may contribute to the progression of pancreatic neoplasia. Ectopic expression of GATA4 gene reduced cell viability and interference of GATA4 expression significantly increased the colony formation ability of pancreatic cancer cells. Furthermore, GATA4 inhibited tumor growth in xenograft mice. Agilent expression microarray profiling analysis indicated that the genes with significant levels of differential expression in GATA4 over-expressing cells were enriched in the cell differentiation process. Analysis of KEGG signaling pathway demonstrated that the regulated genes were partially enriched in MAPK and JAK-STAT signaling pathways. Re-expression of GATA4 up-regulated P53 gene expression. ...Continue Reading

References

Jul 9, 2002·Current Opinion in Genetics & Development·Roger K Patient, James D McGhee
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anirban MaitraRalph H Hruban
Jul 11, 2006·International Journal of Cancer. Journal International Du Cancer·MingZhou GuoJames G Herman
May 24, 2007·Journal of Hepato-biliary-pancreatic Surgery·Georg FeldmannAnirban Maitra
Jul 31, 2007·Cell·Manuel ColladoManuel Serrano
Jul 26, 2008·Endocrinology·Antti KyrönlahtiMikko Anttonen
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Debby M E I HellebrekersManon van Engeland
Mar 12, 2010·World Journal of Gastroenterology : WJG·Xian-Zi WenDa-Jun Deng
Sep 3, 2011·Current Genomics·Yannick DelpuPierre Cordelier
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
May 28, 2014·Cancer Science·Kiyoshi TakagiTakashi Suzuki
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 19, 2015·Archives of Toxicology·Eun Kyung Kim, Eui-Ju Choi
Jul 18, 2015·World Journal of Gastroenterology : WJG·Quan-Jun LinDe-Liang Fu
Sep 3, 2016·Nature Communications·Mandar Deepak MuzumdarTyler Jacks
Feb 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Weiwei ShengJianping Zhou

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Methods Mentioned

BETA
xenograft
transfection
flow cytometry
electrophoresis

Software Mentioned

Oligo Designer
SPSS
GO

Related Concepts

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Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.