PMID: 3760382Nov 1, 1986Paper

Gated blood pool scintigraphic monitoring of doxorubicin cardiomyopathy: comparison of camera and computerized probe results in 101 patients

Journal of the American College of Cardiology
A M StrashunS F Horowitz

Abstract

Serial gated blood pool scintigraphic monitoring of cardiac function with both a nonimaging scintillation probe and a conventional gamma camera-computer imaging system was performed in 101 patients receiving doxorubicin hydrochloride (Adriamycin) chemotherapy. Comparison of probe- and camera-derived ejection fractions (n = 287) correlated significantly (r = 0.70, p less than 0.005) as did the interstudy (n = 183) change in ejection fraction (r = 0.76, p greater than 0.005). Significant discordance in probe- and camera-derived ejection fraction change occurred in 3 (1.6%) of 183 interstudy intervals. Average intrastudy variability of absolute probe-derived ejection fraction was 2.9%. This variability was unrelated to the level of cardiac function. Thirteen patients (13%) developed clinical cardiotoxicity, including four at cumulative Adriamycin levels less than 450 mg/m2. Mean absolute camera ejection fraction decline for these patients was 21% from baseline evaluation, and mean absolute probe ejection fraction decline was 22%. The minimal absolute ejection fraction decline was 11% for patients with clinical congestive heart failure. Eight asymptomatic patients had therapy terminated before the development of clinical cardiotoxi...Continue Reading

References

Feb 8, 1979·The New England Journal of Medicine·J AlexanderB L Zaret
Nov 23, 1976·The American Journal of Cardiology·H N WagnerT K Natarajan
Jul 16, 1981·The New England Journal of Medicine·R C YoungC E Myers
Jan 1, 1982·International Journal of Cardiology·P F Høilund-CarlsenG Jensen

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Citations

May 2, 2002·The Australian and New Zealand Journal of Psychiatry·Brett T Litz, Matt J Gray
Sep 29, 2005·Death Studies·Margaret Stroebe, Henk Schut

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