Gated magnetic resonance imaging of normal and hypertrophied murine hearts

The American Journal of Physiology
F M SiriJ M Gardin

Abstract

Transgenic murine models are being used increasingly to explore the molecular basis of heart disease. Until recently, there were no means for noninvasive assessment of changes in mass and function of the murine heart because of its very small size and high heart rate. Transthoracic echocardiography has now been utilized to obtain noninvasive estimates of murine left ventricular (LV) wall thicknesses, internal dimension, and mass. However, this approach is based on one-dimensional (M-mode) measurements of the LV at its midwall that take no account of variations in LV chamber and wall dimensions along other minor axes and at other anatomic levels. Thus asymmetries in LV geometry, which can affect LV mass estimates, may be undetected. In this study, gated (diastolic) magnetic resonance imaging (MRI) was utilized to obtain two-dimensional images of the LV at four anatomic levels in intact, anesthetized mice. In 17 normal CD-1 mice (body mass, 18-47 g; gravimetric LV mass, 51-135 mg), LV mass estimates produced from the MRI data correlated well (r = 0.87) with LV mass determined gravimetrically. In addition, this approach identified changes in LV mass and wall thickness-to-chamber diameter ratio in a group of seven aortic-constricte...Continue Reading

Citations

Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F WiesmannS Neubauer
Jan 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Ashwin AkkiRobert G Weiss
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R E HensonC H Lorenz
Nov 10, 2001·Annual Review of Biomedical Engineering·T F BudingerA P Koretsky
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S TakumaS Homma
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A E StenbitM J Charron
Jul 10, 2002·ILAR Journal·Craig J HartleyLloyd H Michael

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