Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells

Langmuir : the ACS Journal of Surfaces and Colloids
Cristina GiménezPedro Amorós

Abstract

In recent years, mesoporous silica nanoparticles (MSNs) have been used as effective supports for the development of controlled-release nanodevices that are able to act as multifunctional delivery platforms for the encapsulation of therapeutic agents, enhancing their bioavailability and overcoming common issues such as poor water solubility and poor stability of some drugs. In particular, redox-responsive delivery systems have attracted the attention of scientists because of the intracellular reductive environment related to a high concentration of glutathione (GSH). In this context, we describe herein the development of a GSH-responsive delivery system based on poly(ethylene glycol)- (PEG-) capped MSNs that are able to deliver safranin O and doxorubicin in a controlled manner. The results showed that the PEG-capped systems designed in this work can be maintained closed at low GSH concentrations, yet the cargo can be delivered when the concentration of GSH is increased. Moreover, the efficacy of the PEG-capped system in delivering the cytotoxic agent doxorubicin in cells was also demonstrated.

References

May 16, 2002·Bioconjugate Chemistry·Omayra L Padilla De JesúsFrancis C Szoka
Mar 18, 2004·Journal of the American Chemical Society·Raquel HernandezJeffrey I Zink
Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Sep 6, 2005·Cell Biochemistry and Function·Chih-Ching YehLi-Yu Tsai
Jan 26, 2006·Journal of the American Chemical Society·Rui HongVincent M Rotello
Mar 7, 2006·Critical Reviews in Clinical Laboratory Sciences·José M EstrelaElena Obrador
Aug 29, 2006·Drug Discovery Today·Arun K IyerHiroshi Maeda
Nov 4, 2006·Chemical Communications : Chem Comm·Masahiro FujiwaraHiroyoshi Ohue
Feb 1, 2008·Journal of the American Chemical Society·Kaushik PatelJ Fraser Stoddart
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Frank GuOmid C Farokhzad
May 1, 2009·Journal of the American Chemical Society·Elena AznarCarmen Guillem
Jun 6, 2009·Chemistry : a European Journal·Elena AznarEliseo Ruiz
Sep 11, 2009·Journal of the American Chemical Society·Estela ClimentPedro Amorós
Nov 19, 2009·Journal of the American Chemical Society·Chiyoung ParkChulhee Kim
May 11, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yanzhuo ZhangSiling Wang
Aug 5, 2010·Journal of the American Chemical Society·Courtney R ThomasJeffrey I Zink
Aug 26, 2010·Angewandte Chemie·Estela ClimentPedro Amorós
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Jan 22, 2011·ACS Nano·Eduardo Ruiz-HernándezMaría Vallet-Regí
Jul 9, 2011·Physical Chemistry Chemical Physics : PCCP·Fabiola PortaAlexander Kros
Sep 25, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Alessandro AgostiniSalvador Gil
Sep 25, 2012·Advanced Drug Delivery Reviews·Christine E ProbstXiaohu Gao
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
Dec 12, 2012·Accounts of Chemical Research·Carmen CollFélix Sancenón
Dec 25, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Bivash MandalGeorge C Wood
Jan 3, 2013·Advanced Drug Delivery Reviews·Jose-Maria MontenegroWolfgang J Parak
Apr 24, 2013·Advanced Drug Delivery Reviews·Hedi Mattoussi, Vincent M Rotello
May 11, 2013·Chemical Communications : Chem Comm·Mar OrovalPedro Amorós
Jun 12, 2013·Chemical Communications : Chem Comm·Elena AznarPedro Amorós
Jul 23, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kunn HadinotoWean Sin Cheow
Sep 17, 2013·Regulatory Toxicology and Pharmacology : RTP·Josef Finsterer, Peter Ohnsorge
Feb 13, 2014·Chemical Communications : Chem Comm·Cristina de la TorreEnríque Pérez-Payá
Sep 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shun YangJianmei Lu
Oct 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Srivardhan Reddy Gayam, Shu-Pao Wu

❮ Previous
Next ❯

Citations

Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Na AnFengyu Qu
Nov 14, 2016·Journal of Inorganic Biochemistry·Sara RojasCarmen R Maldonado
Dec 10, 2016·Biomaterials Science·Jingchao LiGuoping Chen
Nov 20, 2016·Chemistry : a European Journal·Mar OrovalRamón Martínez-Máñez
Feb 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adrián H TeruelFélix Sancenón
Nov 20, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Jiasheng XuWeimin Zhou
Jul 1, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ziyuan LiZhongjun Du
Aug 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jonas G CroissantJean-Olivier Durand
Jun 12, 2017·Biochemistry. Biokhimii︠a︡·N A KeasberryA Idris
Dec 2, 2017·Chemistry : a European Journal·Cristina de la TorreFélix Sancenón
Feb 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua ZhuQunwei Xu
Feb 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zihnil Adha Islamy MazradSung Young Park
Aug 1, 2020·Chemistry : a European Journal·Gema Vivo-LlorcaRamón Martínez-Máñez
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Amin AbbasiLeili Aghebati-Maleki
Nov 20, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cristina FuentesMaría José Ruiz
Jan 17, 2021·Pharmaceutics·Isabel González-AlvarezRamón Martínez-Máñez
Jan 7, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongliang HeHu Yang
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajesh SalveWassana Yantasee
Jun 3, 2021·Nanomaterials·Vicente Candela-NogueraRamón Martínez-Máñez
Jul 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alba García-FernándezRamón Martínez-Máñez
Oct 25, 2017·Molecular Pharmaceutics·Marta González-AlvarezFélix Sancenón
May 11, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Chunlin HuXinling Wang
Mar 10, 2017·ACS Applied Materials & Interfaces·Rajendra K SinghHae-Won Kim
Oct 13, 2021·Biomaterials Science·Gulcihan Guzel KayaRamón Martínez-Máñez
Nov 5, 2021·Macromolecular Bioscience·Chengbin YangChih-Kuang Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.