Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting

Expert Opinion on Drug Delivery
Noha M Zaki, Nicola Tirelli

Abstract

The last 10 years have seen a dramatic growth in understanding and controlling how complex, drug-loaded (nano)structures, as well as pathogens, or biopharmaceuticals can gather access to the cytoplasm, which is a key step to increasing the effectiveness of their action. The review offers an updated overview of the current knowledge of endocytic processes; furthermore, the cell surface receptors most commonly used in drug delivery are here discussed on the basis of their reported internalization mechanisms, with examples of their use as nanocarrier targets taken from the most recent scientific literature. Knowledge of molecular biology details is increasingly necessary for a rational design of drug delivery systems. Here, the aim is to provide the reader with an attempt to link a mechanistic knowledge of endocytic mechanisms with the identification of appropriate targets (internalization receptors) for nanocarriers. Much advance is still needed to create a complete and coherent biological picture of endocytosis, but current knowledge already allows individuation of a good number of targetable groups for a predetermined intracellular fate of nanocarriers.

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P M FridenR M Starzyk
Jan 1, 1985·Annual Review of Cell Biology·J L GoldsteinW J Schneider
Jan 1, 1986·Advances in Immunology·G J Gleich, C R Adolphson
Jan 1, 1987·Journal of Neuroscience Research·J B FishmanR E Fine
Jun 19, 1995·Brain Research·S SkarlatosW M Pardridge
Dec 15, 1994·Structure·W I Weis, K Drickamer
Dec 1, 1994·The Journal of Cell Biology·R G PartonK Simons
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J HuwylerW M Pardridge
Jun 1, 1997·Nature Biotechnology·R PasqualiniE Ruoslahti
Aug 8, 1998·Trends in Cell Biology·D DerossiA Prochiantz
Jan 8, 1999·Biochimica Et Biophysica Acta·S R HolladayP S Low
Feb 11, 1999·Neurochemical Research·M E Smith
Mar 4, 1999·International Journal of Pharmaceutics·G J Russell-JonesH Walker
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A LaporteL S Barak
Nov 5, 1999·International Journal of Pharmaceutics·G J Russell-JonesL Arthur
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·P A WenderJ B Rothbard
Nov 17, 2001·The Journal of Biological Chemistry·Tomoki SuzukiYukio Sugiura
Feb 22, 2002·Journal of Biomedical Materials Research·Jon A Rowley, David J Mooney
Mar 19, 2002·International Journal of Pharmaceutics·Jasmine Davda, Vinod Labhasetwar

❮ Previous
Next ❯

Citations

Mar 1, 2012·Chemical Reviews·Tina VermondenWim E Hennink
Feb 14, 2013·ACS Nano·Heather HerdClaus-Michael Lehr
Feb 23, 2013·International Journal of Nanomedicine·Leona DamalakieneRicardas Rotomskis
Jul 31, 2013·Acta Biomaterialia·P Charoenphol, H Bermudez
Apr 2, 2014·BioMed Research International·Sebastien TaurinKhaled Greish
May 9, 2012·Journal of Microencapsulation·Ian G TuckerHimang Mujoo
May 18, 2013·Journal of Drug Targeting·Sebastien TaurinKhaled Greish
Sep 18, 2012·International Journal of Pharmaceutics·Eleonora VighiEliana Leo
Jun 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qihang SunYouqing Shen
May 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dries VercauterenKevin Braeckmans
Oct 15, 2011·Advanced Drug Delivery Reviews·Arnaud E FelberJean-Christophe Leroux
Aug 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meihua SuiYouqing Shen
Jan 8, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Bart Cornelissen
Jun 16, 2012·Particle and Fibre Toxicology·Stephan T SternRachael M Crist
Jul 15, 2015·Neurochemistry International·M D PandareeshM M Srinivas Bharath
May 15, 2015·Macromolecular Bioscience·Rita B RestaniAna Aguiar-Ricardo
Sep 6, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ming KongXiguang Chen
Jun 27, 2013·Biotechnology Advances·Manju Saraswathy, Shaoqin Gong
Jul 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sebastien TaurinKhaled Greish
Feb 8, 2014·Cytotechnology·Violeta Beltran-Sastre, Estanislau Navarro
Jan 27, 2015·Colloids and Surfaces. B, Biointerfaces·Tingxian LiuNa Zhang
Dec 19, 2014·Frontiers in Physiology·Dušan Popov-Čeleketić, Paul M P van Bergen En Henegouwen
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Abou TalibHui-Fen Wu
May 5, 2016·Wiener medizinische Wochenschrift·Aritz Perez Ruiz de Garibay
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingshan QiuWanling Liang
Apr 17, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ayman El-Sayed, Hideyoshi Harashima
Oct 19, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dongwei GuoHoward E Gendelman
Jul 14, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Gamaleldin I HarisaSabry M Attia
Dec 23, 2017·Nanotechnology·Vellampatti SrivithyaPark Sung Ha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Hervé Hillaireau, Patrick Couvreur
Journal of Controlled Release : Official Journal of the Controlled Release Society
Gaurav SahayAlexander V Kabanov
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Kimberly L DouglasMaryam Tabrizian
© 2021 Meta ULC. All rights reserved