Gating and control of primary visual cortex by pulvinar.

Nature Neuroscience
Gopathy PurushothamanVivien A Casagrande

Abstract

The primary visual cortex (V1) receives its driving input from the eyes via the lateral geniculate nucleus (LGN) of the thalamus. The lateral pulvinar nucleus of the thalamus also projects to V1, but this input is not well understood. We manipulated lateral pulvinar neural activity in prosimian primates and assessed the effect on supra-granular layers of V1 that project to higher visual cortex. Reversibly inactivating lateral pulvinar prevented supra-granular V1 neurons from responding to visual stimulation. Reversible, focal excitation of lateral pulvinar receptive fields increased the visual responses in coincident V1 receptive fields fourfold and shifted partially overlapping V1 receptive fields toward the center of excitation. V1 responses to regions surrounding the excited lateral pulvinar receptive fields were suppressed. LGN responses were unaffected by these lateral pulvinar manipulations. Excitation of lateral pulvinar after LGN lesion activated supra-granular layer V1 neurons. Thus, lateral pulvinar is able to powerfully control and gate information outflow from V1.

References

Jan 1, 1979·Neuropsychologia·L G Ungerleider, C A Christensen
Dec 2, 1977·Brain Research·M P Ogren, A E Hendrickson
Apr 1, 1992·Trends in Neurosciences·D L Robinson, S E Petersen
Jan 1, 1991·Cerebral Cortex·D J Felleman, D C Van Essen
Apr 25, 1991·Nature·V S Ramachandran, R L Gregory
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·R DesimoneW Schneider
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R D Rafal, M I Posner
Jan 1, 1987·Neuropsychologia·S E PetersenJ D Morris
Jul 1, 1971·The Journal of Physiology·P O BishopC J Smith
Jan 1, 1995·Annual Review of Neuroscience·R Desimone, J Duncan
Feb 5, 1998·The Journal of Comparative Neurology·K S Rockland
Apr 8, 1998·Annual Review of Neuroscience·E M Callaway
Jan 12, 2001·Journal of Neurophysiology·D B Bender, M Youakim
Feb 15, 2002·Brain : a Journal of Neurology·Hans Otto KarnathChris Rorden
Sep 19, 2003·Journal of Neurophysiology·Sabine KastnerMark A Pinsk
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS
Jan 25, 2005·Nature Neuroscience·Jorge MariñoMriganka Sur
Oct 18, 2005·Progress in Brain Research·David C Van Essen
Apr 17, 2007·Brain Research Reviews·Jon H Kaas, David C Lyon
Nov 9, 2007·Human Brain Mapping·Jason Fischer, David Whitney
Dec 17, 2008·Journal of Neurophysiology·A T SmithC Moutsiana
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jacqueline C SnowGlyn W Humphreys
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Melanie WilkeDavid A Leopold
Feb 4, 2010·The American Journal of Psychiatry·Iliyan IvanovBradley S Peterson
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melanie WilkeDavid A Leopold
Sep 8, 2010·Nature Neuroscience·Nikos K LogothetisHellmut Merkle
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca A Berman, Robert H Wurtz
Jun 17, 2011·Journal of Neurophysiology·S Murray Sherman, R W Guillery
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roberto De Pasquale, S Murray Sherman

❮ Previous
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Citations

Jan 15, 2013·Nature Neuroscience·Xiaolong JiangJ Julius Zhu
Aug 21, 2013·PLoS Computational Biology·Jung H LeeNancy J Kopell
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zita RovóLászló Acsády
Jan 25, 2014·Journal of Cognitive Neuroscience·Leslie G UngerleiderRicardo Gattass
Jan 10, 2016·Neuron·Huihui ZhouRobert Desimone
Jan 11, 2016·Cell Reports·Rebecca A MeaseAlexander Groh
Dec 23, 2015·Nature Neuroscience·Morgane M RothSonja B Hofer
Nov 11, 2015·Trends in Cognitive Sciences·Holly BridgeJames A Bourne
Dec 30, 2015·Schizophrenia Bulletin·Veena KumariDominic H Ffytche
Dec 15, 2015·Cerebral Cortex·Kacie DoughertyAlexander Maier
Feb 5, 2013·The European Journal of Neuroscience·Lucy S PetroLars Muckli
Jul 25, 2012·The Journal of Comparative Neurology·Roan MarionVivien A Casagrande
Aug 19, 2014·Annals of Neurology·Anna Elisabetta VaudanoStefano Meletti
Nov 30, 2013·The Journal of Comparative Neurology·Ricardo GattassLeslie G Ungerleider
Sep 18, 2015·Frontiers in Systems Neuroscience·David N Silverstein, Martin Ingvar
Jul 15, 2015·Progress in Neurobiology·Kelsey ClarkBehrad Noudoost
May 13, 2015·Brain Structure & Function·Andrzej NagalskiMarta B Wisniewska
Feb 14, 2013·Current Opinion in Neurobiology·Lars Muckli, Lucy S Petro
Apr 9, 2015·Frontiers in Systems Neuroscience·Yuri B Saalmann, Sabine Kastner
Apr 1, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ryota KanaiKarl Friston
Jan 9, 2013·Vision Research·Poppy WatsonPieter R Roelfsema
Feb 11, 2015·Progress in Neurobiology·Michael C Schmid, Alexander Maier
Dec 17, 2014·Frontiers in Human Neuroscience·Evelina Leivada, Cedric Boeckx
Nov 10, 2015·Trends in Neurosciences·Thilo Womelsdorf, Stefan Everling
Sep 19, 2016·NeuroImage·Christian LambertThomas R Barrick
Jan 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel ErskineAhmad A Khundakar
Jun 28, 2017·The Journal of Comparative Neurology·Mary K L BaldwinJon H Kaas
Mar 10, 2018·The Journal of Comparative Neurology·Paul R Martin, Samuel G Solomon
Dec 1, 2017·Nature Neuroscience·Michael M Halassa, Sabine Kastner
Apr 6, 2018·Annual Review of Neuroscience·Rajeev V RikhyeMichael M Halassa
Aug 6, 2018·The Journal of Comparative Neurology·Brandon MooreVivien Casagrande
Jan 3, 2018·The Journal of Comparative Neurology·William C KwanJames A Bourne
Feb 15, 2018·The Journal of Comparative Neurology·Georgina A LeanDavid C Lyon

❮ Previous
Next ❯

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