PMID: 9444317Jan 28, 1998Paper

Gavage administration of the fungal toxin fumonisin B1 to female Sprague-Dawley rats

Journal of Toxicology and Environmental Health. Part a
G S BondyM G Barker

Abstract

The fungal toxin fumonisin B1 (FB1) is a contaminant of corn-based foods and feeds produced by members of the genus Fusarium. Fumonisin B1 toxicity was examined using gavage administration of purified toxin to female Sprague-Dawley rats. For 11 consecutive days each rat received a single dose of FB1 at the following concentrations: control (saline), 1, 5, 15, 35, or 75 mg FB1/kg body weight/d. Significantly depressed body weight and food consumption occurred at 35 and 75 mg FB1/kg/d. By the end of the dosing period there were no significant changes in food consumption. Kidneys and bone marrow were most sensitive to FB1 exposure. Changes in renal morphology were observed from 5 to 75 mg FB1/kg/d, accompanied by transient changes in urine osmolality and urine enzyme levels. Increased cellular vacuolation was the primary change associated with bone-marrow toxicity, starting at doses of 5 mg FB1/kg/d. Hepatotoxicity was indicated by reduced liver weight, elevated serum alanine amonitransferase (ALT), and mild histopathological changes occurring at doses of 15 mg FB1/kg/d and higher. Increased cytoplasmic vacuolation of adrenal cortex cells occurred in rats treated with 15 mg FB1/kg/d and higher, indicating that the adrenals are als...Continue Reading

Citations

Oct 20, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G S BondyI H Curran
Jul 31, 2003·Food Additives and Contaminants·K MeyerM Kovács
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Min U YuSeikwan Oh
May 22, 2001·Environmental Health Perspectives·K A VossJ K Porter
Dec 28, 2002·Acta Biologica Hungarica·Ilona Banczerowski-PelyheT Kukorelli
Feb 27, 2009·Human & Experimental Toxicology·H Stockmann-Juvala, K Savolainen
Nov 18, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·E O Ewuola, G N Egbunike

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