Gaviscon® vs. omeprazole in symptomatic treatment of moderate gastroesophageal reflux. a direct comparative randomised trial.

BMC Gastroenterology
Denis PouchainDonna McVey

Abstract

Medical management of GERD mainly uses proton pump inhibitors. Alginates also have proven efficacy. The aim of this trial was to compare short-term efficacy of an alginate (Gaviscon®, 4 × 10 mL/day) and omeprazole (20 mg/day) on GERD symptoms in general practice. A 14-day multicentre randomised double-blind double-dummy non-inferiority trial compared Gaviscon® (4 × 10 mL/day) and omeprazole (20 mg/day) in patients with 2-6 day heartburn episodes weekly without alarm signals. The primary outcome was the mean time to onset of the first 24-h heartburn-free period after initial dosing. Secondary outcomes were the proportion of patients without heartburn by D7, pain relief by D7, and reduction in pain intensity by D7 and D14. 278 patients were recruited; 120 were included in the Gaviscon® group and 121 in the omeprazole group for the per protocol non-inferiority analysis. The mean time to onset of the first 24-h heartburn-free period after initial dosing was 2.0 (± 2.2) days for Gaviscon® and 2.0 (± 2.3) days for omeprazole (p = 0.93); mean intergroup difference was 0.01 ± 1.55 days (95% CI = -0.41 to 0.43): i.e., less than the lower limit of the 95% CI of -0.5 days predetermined to demonstrate non-inferiority. The mean number of he...Continue Reading

References

Jan 1, 1975·Current Medical Research and Opinion·D E BarnardoJ T Wright
Dec 1, 1990·Alimentary Pharmacology & Therapeutics·J R LambertJ G Chan
Jan 26, 1974·Lancet·C Stanciu, J R Bennett
Jan 1, 1972·Current Medical Research and Opinion·M Beeley, J O Warner
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·K G MandelH I Jacoby
Jul 4, 2002·The American Journal of Gastroenterology·Philip MinerSheldon Sloan
Jan 10, 2003·Statistics in Medicine·Ralph B D'AgostinoLisa M Sullivan
Mar 12, 2004·Journal of Gastroenterology and Hepatology·Kwong Ming FockJose Sollano
Aug 4, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bonnie B DeanRonnie Fass
Oct 28, 2004·JAMA : the Journal of the American Medical Association·Robert J F LaheijJan B M J Jansen
Jan 19, 2005·The American Journal of Gastroenterology·Kenneth R DeVaultUNKNOWN American College of Gastroenterology
Feb 3, 2005·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·David ArmstrongUNKNOWN Canadian Association of Gastroenterology GERD Consensus Group
Apr 9, 2005·International Journal of Pharmaceutics·F C HampsonP W Dettmar
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Sandra DialSamy Suissa
Feb 8, 2006·La Presse médicale·Jean-François BretagnePhilippe Barthélemy
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Yu-Xiao YangDavid C Metz
Sep 16, 2008·Gastroenterology·Peter J KahrilasUNKNOWN American Gastroenterological Association
Nov 14, 2008·Current Gastroenterology Reports·Jai Moo Shin, George Sachs
Mar 5, 2009·JAMA : the Journal of the American Medical Association·P Michael HoJohn S Rumsfeld
Aug 10, 2010·European Journal of Clinical Pharmacology·Dirk AhrensMichael M Kochen
Oct 12, 2010·The New England Journal of Medicine·Deepak L BhattUNKNOWN COGENT Investigators
Nov 12, 2010·The New England Journal of Medicine·Mary Ross Southworth, Robert Temple

❮ Previous
Next ❯

Citations

Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Usha Dutta, Paul Moayyedi
Jul 3, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Daniel Sifrim, Roberto Penagini
Mar 5, 2013·Gastroenterology Clinics of North America·Usha Dutta, David Armstrong
Jun 24, 2015·International Journal of Clinical Pharmacy·Helen F Boardman, Gordon Heeley
Jul 24, 2013·Gastroenterology Research and Practice·Yao-Kuang WangChao-Hung Kuo
Jun 22, 2016·Journal of Gastroenterology·Katsuhiko IwakiriTooru Shimosegawa
Sep 28, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D A LeimanJ D Lewis
Nov 8, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Umberto AlecciGioacchino Calapai
Apr 5, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D A LeimanJ D Lewis
Nov 8, 2017·Digestive Diseases and Sciences·Yu-Min KungYao-Kuang Wang
Jan 30, 2013·The American Journal of Gastroenterology·Philip WoodlandDaniel Sifrim
Nov 5, 2015·Journal of Clinical Gastroenterology·David R MitchellKenneth E L McColl
Sep 8, 2020·Expert Opinion on Pharmacotherapy·Nicolas ChapelleMarc Bardou
Oct 9, 2019·Best Practice & Research. Clinical Gastroenterology·Serhat Bor
Aug 14, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Khean-Lee GohReuben Kong-Min Wong

❮ Previous
Next ❯

Software Mentioned

Gaviscon
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
C CaparelloR Penagini
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
O GoetzeW Schwizer
© 2022 Meta ULC. All rights reserved