GB virus-C infection among chronic haemodialysis patients: clinical implications

Journal of Gastroenterology and Hepatology
K OkudaY Irie

Abstract

It is known that patients on chronic haemodialysis are frequently infected with hepatitis C virus (HCV). It has recently been found that GB virus-C (GBV-C) and hepatitis G virus frequently coinfect patients with HCV. This study aimed at elucidating the clinical implications of GBV-C infection among haemodialysis patients who have and do not have HCV infection. GBV-C RNA was detected in sera of randomly selected 98 anti-HCV-positive and 85 -negative patients on dialysis by reverse transcription-polymerase chain reaction using two sets of amplification primers made from the reported sequences of the non-structural protein 3 and 5' untranslated regions. In these patients, liver function tests were carried out at regular intervals. There were six patients who were coinfected with HCV and GBV-C and three who had only GBV-C RNA. All had a history of past blood transfusion. The onset of mild hepatitis was identified in three HCV-negative patients; elevation of alanine aminotransferase (ALT) following blood transfusion was very mild but recognizable, and aspartate aminotransferase (AST) was higher than ALT. In two of six coinfected patients, the onset of liver disease was recognized with a peak ALT of 72 and 90 IU/L, respectively. Two ...Continue Reading

References

Jun 15, 1990·Annals of Internal Medicine·J B ZeldisP V Holland
Jun 1, 1995·Nature Medicine·J N SimonsI K Mushahwar
Jan 18, 1996·The New England Journal of Medicine·T AikawaH Okamoto
Jun 6, 1996·The New England Journal of Medicine·K MasukoM Mayumi
Jun 6, 1996·The New England Journal of Medicine·H J Alter
Oct 31, 1996·The New England Journal of Medicine·M SampietroG Lunghi

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Citations

Sep 11, 1999·Journal of Gastroenterology and Hepatology·T IkeuchiY Irie
Oct 8, 2013·World Journal of Surgical Oncology·Kenji WakayamaAkinobu Taketomi
Jul 16, 2005·Hematology·Eric Prommer
Nov 4, 2000·Journal of Gastroenterology and Hepatology·T KandaH Saisho
Sep 15, 1998·Journal of Gastroenterology and Hepatology·K Okuda
Jul 20, 2004·World Journal of Gastroenterology : WJG·Kunio Okuda, Osamu Yokosuka
May 27, 2021·Reviews in Medical Virology·Joseph Zimmerman, Jason T Blackard

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