GB virus C infection and quality of life in HIV-positive patients

AIDS Care
H L TillmannM Stoll

Abstract

It was recently shown that GBV-C infection is associated with prolonged survival of HIV-infected individuals. The GB virus C is the closest known relative of hepatitis C virus in man. The latter has been associated with significant impairment in quality of life, independent from the associated liver disease. We were thus interested in the impact of GB virus C infection on quality of life in HIV-infected individuals. We retrospectively analyzed a cohort of HIV-positive patients who previously answered the 'HIV-SELT' and the 'EQ-5D' questionnaires assessing quality of life and for whom data on GB virus C RNA status were available. In this study we identified no adverse effect of GB virus C on quality of life, but, in contrast, GB virus C viraemic patients showed better quality of life in all parameters for the scores in comparison to GB virus C-negative HIV-infected patients. HIV-positive patients with a GB virus C infection showed superior quality of life. These data further support the favourable course of HIV disease in GB virus C-positive patients.

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Citations

Jun 1, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mark D BerzsenyiStuart K Roberts
Sep 26, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Solveig TenckhoffHans L Tillmann
Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giovana Lotici Baggio-Zappia, Celso Francisco Hernandes Granato
Feb 12, 2015·Archives of public health = Archives belges de santé publique·Sophie DegrooteDominique M Vandijck
Mar 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vilija R JoyceDouglas K Owens
Jun 19, 2012·Expert Review of Anti-infective Therapy·Carolynne Schwarze-ZanderJuergen K Rockstroh
Aug 7, 2017·Archives of Virology·Bárbara Katharine Barbosa de MirandaAntonio Carlos Rosário Vallinoto

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