PMID: 9175257May 1, 1997Paper

GB virus C/hepatitis G virus infection among Korean patients with liver diseases and general population

Virus Research
Y M ParkB S Kim

Abstract

GB virus C and hepatitis G virus (GBV-C/HGV) have been identified from the patients with acute or chronic liver diseases as possible agents of non-B, non-C hepatitis by two different groups, independently. To investigate whether GBV-C/HGV plays a role among Korean patients with liver diseases, GBV-C/HGV RNA were evaluated in 337 sera by the reverse transcription polymerase chain reaction (RT-PCR) using specific primers derived from 5'-noncoding region of GBV-C/HGV genome. GBV-C/HGV RNA was identified in 11/337 (3.3%). They consisted of 1/160 (0.6%) and 10/177 (3.3%) among the general population and patients with liver diseases, respectively (P < 0.01). Nucleotide sequences of all PCR amplicons were determined by the dideoxy chain termination method and analyzed by molecular evolutionary methods. The phylogenetic tree showed all sequences could be divided into three genotypes. These results indicate that: (1) GBV-C/HGV already exist in Korea; (2) GBV-C/HGV may play some role as an etiologic factor among the Korean patients with liver diseases; (3) GBV-C/HGV infection is rare among Korean general population; and (4) there are at least three different types of GBV-C/HGV in Korea.

References

Jun 1, 1995·Nature Medicine·J N SimonsI K Mushahwar
Mar 2, 1996·Lancet·A J Zuckerman
Jun 6, 1996·The New England Journal of Medicine·K MasukoM Mayumi
Jan 1, 1997·The Journal of Infectious Diseases·R R WuS Iino

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Citations

Feb 15, 2001·Virus Research·L LuS W Im
Nov 4, 2000·Journal of Gastroenterology and Hepatology·T KandaH Saisho
Jan 9, 2009·Journal of Neurophysiology·M J LehmkuhleF E Dudek
Jan 31, 2002·World Journal of Gastroenterology : WJG·J YanM He
Oct 16, 2002·World Journal of Gastroenterology : WJG·Jie YanXiao-Zhi Zhong
May 27, 2021·Reviews in Medical Virology·Joseph Zimmerman, Jason T Blackard

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