GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application

Scientific Reports
Seyedramin PajoumshariatiAlireza Abbaspourrad

Abstract

In periodontics, osteoconductive biodegradable guided bone regeneration (GBR) membranes with acceptable physico-mechanical properties are required to fix alveolar bone defects. The objectives of the present study were to produce and characterize a novel co-polyester-poly (butylene succinate-co-glycolate) (PBSGL), and fabricate a PBSGL membrane by electrospinning. We then aimed to evaluate the in vitro effect of the glycolate ratio on the biocompatibility and osteogenic differentiation of mesenchymal stem cells (MSCs), and evaluate in vivo bone regeneration using these membranes in rabbit calvarial defects by histology. Increasing the glycolate ratio of electrospun PBSGL membranes resulted in better cell attachment, greater cell metabolic activity, and enhanced osteogenic potential at both transcriptional and translational levels. Histologic and histomorphometric evaluations revealed further that bone defects covered with fibers of higher glycolate ratios showed more bone formation, with no adverse inflammatory response. These results suggest that novel PBSGL electrospun nanofibers show great promise as GBR membranes for bone regeneration.

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Citations

Jul 30, 2019·Frontiers in Chemistry·Yu ZhuangHongbo Yu
Aug 31, 2020·Advanced Healthcare Materials·Paola AprileTeresa Simon-Yarza
Jan 11, 2019·International Journal of Biomaterials·Ziyu GeYanzhen Zhang

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differential scanning calorimetry
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