GC-IRD studies on regioisomeric ring substituted methoxy methyl phenylacetones related to 3,4-methylenedioxyphenylacetone

Forensic Science International : Synergy
Tamer AwadC Randall Clark

Abstract

The methoxy methyl phenylacetones share an isobaric relationship (equivalent mass but different elemental composition) to the controlled precursor substance 3,4-methylenedioxyphenylacetone (3,4-methylenedioxyphenyl-2-propanone; 3,4-MDP-2-P). The ten ring substituted methoxy methyl phenylacetones are resolved by capillary gas chromatography on a modified cyclodextrin stationary phase. All ten regioisomeric ketones eluted before the controlled precursor substance 3,4-methylenedioxyphenylacetone. The vapor phase infrared spectra generated from the capillary column effluent clearly differentiated 3,4-MDP-2-P from the various methoxy methyl phenylacetones. Additionally the methoxy methyl phenylacetones provide unique individual infrared spectra. Infrared absorption frequencies and patterns confirmed the relative position of the methoxy-group and the acetone side-chain for the regioisomeric ketones.

References

Oct 1, 1988·Journal of Chromatographic Science·W Duncan, W H Soine
Sep 21, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·E Schneiderman, A M Stalcup
Jan 20, 2009·Forensic Science International : Synergy·Tarek BelalC Randall Clark
Feb 3, 2009·Forensic Science International : Synergy·Tamer AwadC Randall Clark

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Citations

Mar 23, 2011·Forensic Science International : Synergy·Karim M Abdel-HayC Randall Clark
May 3, 2011·Analytical Chemistry·T A BrettellJ R Almirall

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