GC-MS analysis of the designer drug α-pyrrolidinovalerophenone and its metabolites in urine and blood in an acute poisoning case

Forensic Science International : Synergy
Marcel GrappDieter Müller

Abstract

α-Pyrrolidinovalerophenone (α-PVP) is a synthetic cathinone belonging to the group of "second generation" pyrrolidinophenones that becomes more and more popular as a designer psychostimulant. Here we provide toxicological analytical support for a severe poisoning with α-PVP. Serum and urine samples that were sent to our laboratory were subjected to a general unknown screening procedure. The procedure includes immunoassay-based screening of drugs of abuse in serum and systematic toxicological analysis of urine and serum after neutral and basic liquid-liquid extraction followed by gas chromatography-mass spectrometry (GC-MS). Whereas the immunoassay delivered negative results, analyzing the urine sample by GC-MS in full scan mode disclosed the presence of α-PVP and its metabolites α-(2″-oxo-pyrrolidino)valerophenone (2″-oxo-α-PVP) and 1-phenyl-2-(pyrrolidin-1-yl)pentan-1-ol (OH-α-PVP). In the acetylated urine sample we found additionally N,N-bis-dealkyl-PVP. In serum, α-PVP could be detected after solid phase extraction and a concentration of 29ng/mL was determined. Other forensic relevant substances were not detected. The presented data can explain the psychotic symptoms and behavioural pattern of the subject after abuse of α-PV...Continue Reading

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Citations

Jul 15, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Olof BeckAnders Helander
Mar 16, 2018·Drug Metabolism Reviews·Leandro Nóbrega, Ricardo Jorge Dinis-Oliveira
Dec 3, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Piotr Adamowicz
Jan 1, 2021·International Journal of Molecular Sciences·Jeremy CarlierMarilyn A Huestis
Dec 17, 2020·Journal of Analytical Toxicology·Alex J KrotulskiBarry K Logan
Apr 3, 2021·Frontiers in Chemistry·Ana-Maria DraganRadu Oprean
Jun 9, 2021·Archives of Toxicology·Jorge SoaresJoão Paulo Capela

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