GC-MS-based metabolomics, antibacterial and anti-inflammatory investigations to characterize the quality of essential oil obtained from dried Xylopia aethiopica fruits from Ghana and Nigeria

The Journal of Pharmacy and Pharmacology
Raphael N AlolgaVitus Onoja

Abstract

This study sought to determine the quality of essential oil from Xylopia aethiopica fruits of different geographical origins using GC-MS-based metabolomics, bacterial quorum sensing and anti-inflammation assessment. Essential oil was obtained from eight batches of X. aethiopica fruits from Ghana and Nigeria by hydrodistillation, characterized using gas chromatography-mass spectrometry and differences therein found using metabolomics. The respective antibacterial activity of the oils was tested against four bacterial strains: two Gram-positive strains, Staphylococcus aureus (ATCC 25923) and Bacillus licheniformis (ATCC12759), and two Gram-negative strains, Escherichia coli (ATCC25922) and Klebsiella pneumoniae (ATCC 13883). Anti-inflammation was tested using RAW 264.7 macrophage cells. The outcome of the study revealed that the oil of the Ghana-sourced samples exhibited superior antibacterial, cytotoxic and anti-inflammatory effects than those from Nigeria. This could be attributed to the higher levels of the bioactive compounds present in those samples. This distinction between the samples from the two countries was clearly established using the metabolomics approach, and 14 differential metabolites were found to be potential c...Continue Reading

References

May 21, 1999·Science·J W CostertonE P Greenberg
Nov 6, 2003·Phytochemistry·Fabrice Fekam BoyomPhilip J Rosenthal
Dec 25, 2003·Fitoterapia·G H KonningB Ennison
Apr 21, 2007·Microbiology and Immunology·Mohammad Sirajul IslamGary K Schoolnik
Jul 23, 2008·Antimicrobial Agents and Chemotherapy·Mette E SkindersoeMichael Givskov
Jan 1, 2008·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·T C FleischerH Skaltsa
Mar 14, 2012·Cell Division·Aphrodite T ChoumessiAnnie Valette
Jun 5, 2012·Journal of Bacteriology·Disha Srivastava, Christopher M Waters
Apr 25, 2014·Journal of Food Science·N A Vyry WouatsaR Venkatesh Kumar
Jun 4, 2016·International Journal of Molecular Sciences·Jun HongJianxin Shi
Jan 11, 2017·Infection and Immunity·Sai Siddarth KalburgeE Fidelma Boyd
May 10, 2017·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Arif Şanli, Tahsin Karadoğan
May 10, 2017·Journal of Bacteriology·Alyssa S BallJulia C van Kessel

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