GCF and serum myeloperoxidase and matrix metalloproteinase-13 levels in renal transplant patients

Archives of Oral Biology
Gülnur EmingilTimo Sorsa

Abstract

The rationale of this study was to address whether local or systemic changes reflect proteolytic (matrix metalloproteinase-13) or oxidative (myeloperoxidase) stress in renal transplant patients receiving cyclosporine-A (CsA) and having gingival overgrowth (GO), in patients receiving CsA therapy and having no GO and patients receiving tacrolimus therapy. Gingival crevicular fluid (GCF) samples were collected from sites with (GO+) and without GO (GO-) in CsA patients having GO; GO- sites in CsA patients having no GO; sites from tacrolimus, gingivitis and healthy subjects. GCF and serum myeloperoxidase (MPO) and matrix metalloproteinase-13 (MMP-13) levels were determined by ELISA. GO+ sites in CsA patients having GO had elevated GCF MPO levels than those of CsA patients having no GO, tacrolimus and healthy subjects (p<0.005), but comparable to those of gingivitis. GCF MPO levels were higher in GO+ compared to GO- sites in CsA patients having GO (p<0.05). Patient groups had similar, but higher GCF MMP-13 levels than healthy group. These results show that CsA and tacrolimus therapy have not a significant effect on GCF MPO and MMP-13 levels, and gingival inflammation seems to be the main reason for their elevations.

References

Jun 1, 1991·Journal of Cellular Biochemistry·D A TiptonM K Dabbous
Sep 28, 1990·Biochemical and Biophysical Research Communications·H SaariT Sorsa
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Jan 1, 1989·Journal of Clinical Periodontology·C F Cao, Q T Smith
Jun 1, 1989·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·U BergmannH Tschesche
Aug 3, 1989·The New England Journal of Medicine
Dec 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·A P Angelopoulos, P W Goaz
May 1, 1983·Journal of Clinical Periodontology·E M Rateitschak-PlüssG Thiel
Mar 1, 1996·Journal of Clinical Periodontology·R A SeymourJ S Ellis
Mar 9, 2000·Transplantation·D W ThomasG R Osborne
Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A FornoniL J Striker
May 16, 2003·Journal of Periodontology·Paula L HylandChris R Irwin
Mar 17, 2004·Journal of Clinical Periodontology·J S EllisJ M Thomason
Sep 22, 2005·Journal of Clinical Periodontology·Nicoletta GaglianoMagda Gioia
Apr 17, 2007·Journal of Clinical Periodontology·Ricardo Takiy SekiguchiRoberto Fraga Moreira Lotufo
Aug 25, 2007·Journal of Clinical Periodontology·Marcela HernándezJorge Gamonal
Aug 28, 2007·Journal of Dental Research·A KantarciP C Trackman
Feb 22, 2008·Mediators of Inflammation·Ivan BorgesTânia Silvia Fröde
Sep 9, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P Sivakumar, A M Das

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.