GCN5L1/BLOS1 Links Acetylation, Organelle Remodeling, and Metabolism

Trends in Cell Biology
Iain ScottMichael N Sack

Abstract

General control of amino acid synthesis 5 (GCN5) like-1 (GCN5L1) was identified as a novel gene with sequence homology to the histone acetyltransferase Gcn5. Subsequent protein-interaction studies identified GCN5L1 as a subunit of the multiprotein lysosome biogenesis complex, resulting in an alternative designation as biogenesis of lysosome-related organelle complex 1 subunit 1 (BLOS1 or BLOC1S1). Despite the distinct nomenclatures, GCN5L1/BLOS1 has been shown to play crucial roles in mitochondria, endosomes, lysosomes, and synaptic vesicle precursors (SVPs). GCN5L1/BLOS1 controls mitochondrial protein acetylation, modulates metabolic pathways, and orchestrates retrograde mitochondria-to-nucleus signaling. It also contributes to endosome-lysosome and vesicle trafficking and to endolysosomal function. Here we discuss the intracellular roles of GCN5L1/BLOS1 in the hope of linking mitochondria-centric effects to cytosolic vesicle biology.

References

Oct 31, 1995·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T K WatanabeY Hirai
Jan 13, 1998·Gene·C A DriessenJ J Janssen
Feb 20, 1999·The Journal of Biological Chemistry·P A GrantJ L Workman
Dec 18, 2009·Human Molecular Genetics·Verónica T CheliEsteban C Dell'Angelica
Aug 7, 2010·Molecular & Cellular Proteomics : MCP·Florian GnadMatthias Mann
Mar 15, 2011·Cancer Cell·Lydia W S FinleyMarcia C Haigis
Nov 15, 2011·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Nov 17, 2011·Free Radical Biology & Medicine·Bradley R WebsterIain Scott
Dec 5, 2012·Cold Spring Harbor Perspectives in Biology·Michael N Sack, Toren Finkel
May 10, 2013·Nature Reviews. Molecular Cell Biology·Jeffrey R SkaarMichele Pagano
Aug 22, 2013·Journal of Structural and Functional Genomics·Hai-Bin LuoWladek Minor
Sep 6, 2013·Journal of Cell Science·Bradley R WebsterMichael N Sack
Dec 18, 2013·Molecular and Cellular Biology·Sadhana A SamantMahesh P Gupta
Feb 15, 2014·Biochimica Et Biophysica Acta·Bradley R WebsterMichael N Sack
Apr 15, 2014·Molecular Cell·Gregory R Wagner, Matthew D Hirschey
Jun 27, 2014·Cardiovascular Research·Osama Abo AlrobGary D Lopaschuk
Jul 24, 2014·Nature Reviews. Molecular Cell Biology·Chunaram ChoudharyMatthias Mann
Apr 22, 2015·Developmental Cell·Jing PuJuan S Bonifacino
Jun 16, 2015·Cell Metabolism·Navdeep S Chandel
Jun 5, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Arata FukushimaGary D Lopaschuk
Mar 21, 2017·Nature Cell Biology·Valerio DonatoMichele Pagano
May 13, 2017·Science·Peter J ThulEmma Lundberg
May 21, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Dharendra ThapaIain Scott
Aug 22, 2017·Current Biology : CB·Shinsuke NiwaKang Shen

❮ Previous
Next ❯

Citations

Jan 9, 2019·Antioxidants & Redox Signaling·Sergey I Dikalov, Anna E Dikalova
Feb 23, 2019·The Journal of Cell Biology·Donghwi BaeJulie Hollien
Jul 26, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lingdi WangMichael N Sack
May 10, 2020·Journal of Cellular and Molecular Medicine·Coert J ZuurbierThomas Krieg
Sep 11, 2018·Frontiers in Oncology·Giuseppe CanninoAndrea Rasola
Nov 25, 2019·Journal of Physiology and Biochemistry·Tingting LvQiang Wan
Dec 14, 2018·Frontiers in Pharmacology·Antonella StoppacciaroPatrizia Filetici
Jul 1, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Kaiyuan WuMichael N Sack
Oct 20, 2019·Journal of Molecular Biology·Jaime Santo-DomingoAndreas Wiederkehr
Aug 26, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Brittany N Albaugh, John M Denu
Feb 8, 2020·Molecular Aspects of Medicine·L DardR Rossignol
Feb 19, 2019·Journal of Molecular and Cellular Cardiology·Janet R ManningIain Scott
Apr 21, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Aida M Bertoli-AvellaPeter Bauer
Aug 26, 2021·Biological Chemistry·Anna-Theresa BlaslMichael Lammers
Jul 29, 2021·American Journal of Physiology. Cell Physiology·Jessica N PeoplesJennifer Q Kwong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.