Gd-DTPA-coupled Ag2 Se quantum dots for dual-modality magnetic resonance imaging and fluorescence imaging in the second near-infrared window

Nanoscale
Jiao-Jiao MaDai-Wen Pang

Abstract

Near-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to fabricate multifunctional contrast agents for multimodal imaging. Herein, second near-infrared window fluorescent (NIR-II) Ag2Se QDs were coupled with gadopentetate dimeglumine injection (Gd-DTPA) for dual-modality T1-weighted magnetic resonance (MR) imaging and fluorescence imaging. In vitro experiments suggested that the prepared Ag2Se-Gd QDs exhibit low cytotoxicity, remarkable T1-weighted MR imaging, and fluorescence imaging contrast properties. In vivo experiment results showed that Ag2Se-Gd QDs were the preferred contrast agents for dual-modality T1-weighted MR imaging and fluorescence imaging with high spatial resolution. Moreover, excellent temporal resolution and high tissue penetration depth were also achieved by fluorescence imaging. These results indicate the potential of Ag2Se-Gd QDs as multifunctional contrast agents for multimodal imaging in clinical diagnosis and research.

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Citations

Jan 4, 2019·Nanoscale·Xiangjun HanKhashayar Farsad
Apr 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Baofeng YunZhen Li
Dec 20, 2020·Colloids and Surfaces. B, Biointerfaces·Lianjiang Tan, Changyu He
Mar 16, 2021·IScience·Hélio M GilGraeme J Stasiuk
Oct 17, 2019·ACS Applied Materials & Interfaces·Dan SongZhihong Liu
Nov 17, 2021·Nanoscale·Lenitza M NievesDavid P Cormode

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Methods Mentioned

BETA
fluorescence imaging
X-ray
dynamic light scattering
electrophoresis
gel filtration

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