Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance

Biomaterials
Ao XiaFuyou Li

Abstract

Multimodality molecular imaging has recently attracted much attention, because it can take advantage of individual imaging modalities by fusing together information from several molecular imaging techniques. Herein, we report a multifunctional lanthanide-based nanoparticle for near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence (UCL), X-ray computed tomography (CT) and T(1)-enhanced magnetic resonance (MR) trimodality in-vivo imaging. By careful selection of the lanthanide elements, core-shell structured lanthanide-based nanoparticles, NaLuF(4):Yb(3+),Tm(3+)@SiO(2)-GdDTPA nanoparticles (UCNP@SiO(2)-GdDTPA) have been designed and synthesized. We also prove that the application of UCNP@SiO(2)-GdDTPA for NIR-to-NIR UCL, CT and MRI multi-modality in-vivo imaging can be established successfully. In addition, the biological toxicity of UCNP@SiO(2)-GdDTPA is evaluated by the methyl thiazolyl tetrazolium (MTT) assay and histological analysis of viscera sections.

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Citations

Jun 15, 2013·Journal of the American Chemical Society·Yi LiuFuyou Li
May 7, 2013·Annual Review of Biomedical Engineering·Gang BaoSheng Tong
Jan 21, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Wenyan YinYuliang Zhao
Mar 5, 2013·Annual Review of Analytical Chemistry·Susana Carregal-RomeroWolfgang J Parak
Oct 27, 2012·Biomaterials·Yang YangFuyou Li
Dec 17, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Chunyan CaoJung Hyun Jeong
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Claudia A GrilloMónica A Fernández Lorenzo de Mele
Dec 12, 2012·Angewandte Chemie·Datao TuXueyuan Chen
Apr 5, 2013·Advanced Materials·Nohyun LeeTaeghwan Hyeon
Aug 29, 2013·Advanced Materials·Wei FengFuyou Li
Mar 19, 2013·Chemistry : a European Journal·Datao TuXueyuan Chen
Jul 6, 2014·Contrast Media & Molecular Imaging·Vahid Shirshahi, Madjid Soltani
Jul 18, 2015·Small·James RieffelJonathan F Lovell

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