GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways

Laboratory Investigation; a Journal of Technical Methods and Pathology
Naoki UrakawaHiroshi Yokozaki

Abstract

Tumor-associated macrophages (TAMs) are known to be involved in the progression, angiogenesis, and motility of various cancers. We previously reported the association between an increased number of infiltrating TAMs with tumor progression and poor prognosis in esophageal squamous cell carcinomas (ESCCs). To study the roles of TAMs in ESCC, we first exposed peripheral blood monocyte (PBMo)-derived macrophages from healthy volunteers to conditioned media of TE series human ESCC cell line (TECM) and confirmed the induction of the expression of the M2 macrophage marker CD204 and the protumorigenic factors interleukin (IL)-10, VEGFA, and MMPs. Next, we compared gene expression profiles between PBMo-derived macrophages stimulated with or without TECM by cDNA microarray and focused on growth differentiation factor 15 (GDF15) among the highly expressed genes including IL-6, IL-8, and CXCL1. Our immunohistochemical study of 70 surgically resected ESCCs revealed that GDF15 was present not only in cancer cells but also in macrophages. The high expression of GDF15 in the ESCCs was significantly correlated with several more malignant phenotypes including vessel invasion, lymph node metastasis, and clinical stages. Patients with high GDF15 e...Continue Reading

References

Jul 1, 1995·World Journal of Surgery·P Hermanek, C Wittekind
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BootcovS N Breit
Nov 5, 1997·Journal of Biochemistry·M Yokoyama-KobayashiS Kato
Dec 31, 1997·Biochimica Et Biophysica Acta·R HromasL Lu
May 24, 2003·Biochemical and Biophysical Research Communications·Dev KaranSurinder K Batra
Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Yasumasa NishimuraUNKNOWN Japanese Society for Esophageal Diseases
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 16, 2005·Cancer Cell·Frances BalkwillAlberto Mantovani
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens KoopmannMichael Goggins
Feb 18, 2006·Circulation Research·Tetsuro Ago, Junichi Sadoshima
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten HagemannFrances R Balkwill
Sep 13, 2006·Cancer Metastasis Reviews·Alberto MantovaniAntonio Sica
Aug 4, 2007·International Journal of Cancer. Journal International Du Cancer·Toru HiyamaKazuaki Chayama
Aug 6, 2008·Nature Clinical Practice. Gastroenterology & Hepatology
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chunyu ZhangXin-Yuan Guan
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Bin LiAnnie L M Cheung
Oct 22, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A BrownFredrik E Wiklund
Jun 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Graziella SolinasPaola Allavena
Jun 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick RothJörg Wischhusen
Jun 26, 2010·Journal of Cellular Physiology·Murielle Mimeault, Surinder K Batra
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 2, 2011·Cancer Science·Yoshihiro KomoharaMotohiro Takeya
Oct 30, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine D GruganRandall J Brezski
Dec 12, 2012·Biochemical Pharmacology·Xingya WangThomas E Eling
May 28, 2013·Molecular and Cellular Biochemistry·Fengxia LiuWenya Liu
Jan 25, 2014·International Journal of Cancer. Journal International Du Cancer·Ole HelmSusanne Sebens
Apr 17, 2014·Cancer Research·Julie M LoweMichael A Resnick
May 2, 2014·Cancer Research·Francesca BruzzeseMartin Augsten

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Citations

Nov 21, 2015·Biochimica Et Biophysica Acta·Michael GliemSebastian Jander
May 4, 2016·Oncoimmunology·Gerhard HamiltonMaximilan J Hochmair
Apr 6, 2019·Current Pharmaceutical Design·Lei FangChundong Gu
Oct 27, 2015·Oncotarget·Chen LiMaode Lai
May 28, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takayuki KodamaHiroshi Yokozaki
Oct 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dong HanYan Gao
Dec 23, 2017·Archives of Toxicology·Marzieh NejabatBettina Grasl-Kraupp
Aug 9, 2020·Cancer Management and Research·Peng HanFan Li
Jan 27, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nobuhide HigashinoHiroshi Yokozaki
Jun 7, 2020·Clinical & Experimental Metastasis·Anna Spanopoulou, Vasiliki Gkretsi
Apr 19, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Luc RochetteCatherine Vergely
Jan 3, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Maiko OkamotoHiroshi Yokozaki

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