GDF15 promotes epithelial-to-mesenchymal transition in colorectal [corrected

Artificial Cells, Nanomedicine, and Biotechnology
Yifei ZhangLeping Li

Abstract

Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor-β (TGF-β) superfamily that has been associated with colorectal cancers (CRC). However, the role of GDF15 in the progression of CRC remains unknown. We demonstrated that GDF15 expression was higher in fresh CRC tissues than in adjacent normal tissues. Moreover, we found that GDF15 overexpression significantly facilitated cell viability, cell invasion and migration (p < .01 or p < .05). The protein expression of N-cadherin, vimentin and Twist1 were up-regulated by GDF15 overexpression, while E-cadherin was down-regulated. Reciprocally, using a GDF15-shRNA strategy, we observed that GDF15 downregulation inhibited both basal and GDF16-induced cell viability, invasion and migration in LoVo cells. In conclusion, GDF15 could promote cell viability, invasion and migration of LoVo cells through EMT induction.

References

Nov 30, 2005·Nucleic Acids Research·Cindy VandewalleGeert Berx
Feb 18, 2006·Circulation Research·Tetsuro Ago, Junichi Sadoshima
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
May 18, 2007·Nature Reviews. Cancer·Héctor PeinadoAmparo Cano
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jan 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Melissa G MendezRobert D Goldman
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
May 28, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne Cathrine StaffHelga B Salvesen
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward

❮ Previous
Next ❯

Citations

Apr 6, 2019·Current Pharmaceutical Design·Lei FangChundong Gu
Jun 9, 2020·Frontiers in Immunology·Jörg WischhusenWolf Herman Fridman
Jun 26, 2021·Current Medical Science·Sylwia MielcarskaElżbieta Świętochowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.