GDNF--a potential target to treat addiction.

Pharmacology & Therapeutics
Sebastien Carnicella, Dorit Ron

Abstract

The glial cell line-derived neurotrophic factor (GDNF) is a secreted protein, best known for its role in the development of the central and peripheral nervous systems and the survival of adult dopaminergic neurons. More recently, accumulating evidence suggests that GDNF plays a unique role in negatively regulating the actions of drugs of abuse. In this article, we review these data and highlight the possibility that the GDNF pathway may be a promising target for the treatment of addiction.

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Jul 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Moses V Chao
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Segev BarakDorit Ron
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun WangDorit Ron
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Mar 24, 2009·Alcoholism, Clinical and Experimental Research·Sebastien CarnicellaDorit Ron
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