GDNF-induced seminomatous tumours in mouse--an experimental model for human seminomas?

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
H Sariola, Xiaojuan Meng

Abstract

Glial-cell-line-derived neurotrophic factor (GDNF) is a distant member of the transforming growth factor superfamily. It binds to and activates a receptor complex consisting of GFR-alpha1 and Ret receptor tyrosine kinase. In testis, GDNF is expressed by Sertoli cells. We have shown by transgenic loss- and gain-of-function mouse models that GDNF regulates the cell fate decision of undifferentiated spermatogonia. In the GDNF +/- mice, the spermatogonia differentiate in excess leading to the depletion of germ cells. In the mice overexpressing GDNF in testes, undifferentiated spermatogonia accumulate in the tubules, no sperm is produced, and the mice are infertile. After a year, the GDNF overexpressing mice frequently (89%) develop testicular tumours, and most of them are bilateral (56%). All these tumours show the same histological pattern. They are composed of round spermatogonial/gonocytic cells with only a scant cytoplasm. The tumours are locally invasive but do not metastasise. They express germ line markers, are positive for alkaline phosphatase, and aneuploid with a triploid peak. Thus, by several histological, molecular, and histochemical characteristics, the GDNF-induced tumours mimic classical seminomas in men, but the pr...Continue Reading

References

Sep 11, 1990·Nucleic Acids Research·S Mizushima, S Nagata
Feb 1, 1995·Molecular Reproduction and Development·U KoshimizuY Nishimune
Jul 4, 1996·Nature·M W MooreA Rosenthal
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q C VegaG R Dressler
Jun 5, 1999·Molecular and Cellular Neurosciences·M S AiraksinenM Saarma
Jun 5, 1999·Reviews of Reproduction·L H Looijenga, J W Oosterhuis
Feb 28, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·D G de Rooij
May 4, 2002·Nature Reviews. Neuroscience·Matti S Airaksinen, Mart Saarma

❮ Previous
Next ❯

Citations

Aug 12, 2005·Cell and Tissue Research·Catherine M BrowneKate L Loveland
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Wolter Oosterhuis, Leendert H J Looijenga
May 20, 2008·Molecular and Cellular Endocrinology·Marie-Claude Hofmann
Oct 13, 2015·Seminars in Cell & Developmental Biology·Susanna DolciMassimo De Felici
Nov 28, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Nan Xiao, Quynh-Thu Le
Jul 13, 2005·Molecular Reproduction and Development·Kevin T EbataMakoto C Nagano
Mar 6, 2010·International Journal of Andrology·N ChevalierP Fénichel
Feb 24, 2012·Biology of Reproduction·Hiroko MorimotoTakashi Shinohara
Aug 16, 2019·Nature Reviews. Cancer·J Wolter Oosterhuis, Leendert H J Looijenga
Oct 30, 2019·International Journal of Molecular Sciences·Leendert H J LooijengaMuhammad T Idrees
Jun 19, 2012·Reproductive Medicine and Biology·Masanori ImamuraHideyuki Okano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.