Geant4-DNA track-structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

Medical Physics
Dousatsu SakataSébastien Incerti

Abstract

Gold nanoparticles (GNPs) are known to enhance the absorbed dose in their vicinity following photon-based irradiation. To investigate the therapeutic effectiveness of GNPs, previous Monte Carlo simulation studies have explored GNP dose enhancement using mostly condensed-history models. However, in general, such models are suitable for macroscopic volumes and for electron energies above a few hundred electron volts. We have recently developed, for the Geant4-DNA extension of the Geant4 Monte Carlo simulation toolkit, discrete physics models for electron transport in gold which include the description of the full atomic de-excitation cascade. These models allow event-by-event simulation of electron tracks in gold down to 10 eV. The present work describes how such specialized physics models impact simulation-based studies on GNP-radioenhancement in a context of x-ray radiotherapy. The new discrete physics models are compared to the Geant4 Penelope and Livermore condensed-history models, which are being widely used for simulation-based NP radioenhancement studies. An ad hoc Geant4 simulation application has been developed to calculate the absorbed dose in liquid water around a GNP and its radioenhancement, caused by secondary parti...Continue Reading

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Jun 7, 2018·Physics in Medicine and Biology·Wonmo Sung, Jan Schuemann
Oct 6, 2019·Scientific Reports·Yaser Hadi GholamiZdenka Kuncic
Feb 12, 2020·Physics in Medicine and Biology·M C FussM Krämer
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Aug 18, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Gilnaz OmyanFaraz Kalantari
Feb 26, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Tara GrayKathryn M Mayer
Mar 26, 2021·Scientific Reports·Marc Benjamin Hahn, Julián Mateo Zutta Villate
May 1, 2021·International Journal of Molecular Sciences·Marie HulloEmmanuelle Bourneuf

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