Gefitinib-Induced Interstitial Lung Disease in Korean Lung Cancer Patients

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Seung-Hoon BeomDae Seog Heo

Abstract

Interstitial lung disease (ILD) is a serious adverse effect of gefitinib. We examined the incidence and clinical characteristics of drug-induced ILD in Korean non-small cell lung carcinoma patients treated with gefitinib. A retrospective cohort study was performed in non-small cell lung cancer (NSCLC) patients who started gefitinib treatment at Seoul National University Hospital from January 2002 through December 2011. Patients who developed new abnormal radiologic findings with respiratory symptoms after gefitinib treatment were defined as having possible adverse pulmonary reactions. The patients' medical records were reviewed independently by investigators to identify the causes of pulmonary toxicities. Among the 1,114 patients evaluated, 128 patients (11.5%) developed pulmonary adverse reactions after taking gefitinib. An infectious complication occurred in 98 patients (8.8%) and 15 patients (1.3%) developed ILD. Nine of the 15 patients (60.0%) with gefitinib-induced ILD experienced a fatal clinical course that met either the Common Terminology Criteria for Adverse Events grade 4 (n=3) or grade 5 (n=6). In the multivariate analysis, a lower serum albumin level (≤ 3.0 g/dL) at baseline was significantly associated with the de...Continue Reading

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Citations

Feb 10, 2016·Diagnostic and Interventional Imaging·G R FerrettiA C Toffart
Aug 19, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rashmi R Shah
Jan 9, 2021·The Korean Journal of Internal Medicine·Min-Young LeeJong-Ho Won
Jan 22, 2021·Seminars in Cancer Biology·Alessio BasoloFerruccio Santini

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