PMID: 11913570Mar 27, 2002Paper

Gelastic seizure with hypothalamic hamartoma: proton magnetic resonance spectrometry and ictal electroencephalographic findings in a 4-year-old girl

Journal of Child Neurology
Shuji WakaiHiroyuki Hayasaka

Abstract

Gelastic seizure is a rare symptom often associated with hypothalamic hamartoma. We present here a 4-year-old girl with gelastic epilepsy caused by hypothalamic hamartoma and report the magnetic resonance spectrometry and electroencephalographic (EEG) findings. At the age of 2 1/2 years, she developed brief, repetitive laughing attacks or mixed attacks with laughing and crying, which were refractory to carbamazepine. An interictal EEG showed intermittent slow waves in the left frontocentral region and sporadic positive sharp waves in the left centroparietal area. Ictal EEG demonstrated dysrhythmic theta activity in the left central area 3 seconds after the onset of laughing. Brain magnetic resonance imaging demonstrated a large sessile mass, isointense to gray matter, in the region of the hypothalamus, suggesting hypothalamic hamartoma. Proton magnetic resonance spectrometry of the hypothalamic hamartoma revealed a significant reduction of the N-acetylaspartate/serum creatinine ratio. The altered chemical shift imaging with magnetic resonance spectrometry in our patient suggests a biochemical abnormality in the tissue of the hypothalamic hamartoma. Moreover, this abnormal function of the hamartoma tissue might be closely relate...Continue Reading

References

Oct 1, 1976·American Journal of Diseases of Children·P K Sher, S B Brown
Aug 1, 1992·Clinical Pediatrics·P IannettiL Bozzao
Apr 1, 1989·Journal of Neurosurgery·S NishioM Fukui
May 1, 1995·Pediatric Neurology·H AsanumaS Chiba
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·C MunariO O Betti
Feb 1, 1995·The Australian & New Zealand Journal of Obstetrics & Gynaecology·N A Beischer
Aug 1, 1993·Brain : a Journal of Neurology·S ArroyoR S Fisher
Jul 1, 1997·Annals of Neurology·R KuznieckyH G Liu

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Citations

Mar 17, 2004·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Göran BrandbergOrvar Eeg-Olofsson
Jun 4, 2013·Neurosurgical Focus·Sandeep MittalFrederick Andermann
Sep 8, 2012·Epilepsy Research and Treatment·Nathalie T SanonLionel Carmant
Dec 17, 2008·European Journal of Orthodontics·P W WoodsL A Opperman
Aug 28, 2010·Journal of Clinical Periodontology·Juan BlancoFernando Muñoz
Aug 25, 2005·Clinical Oral Implants Research·Els De SmetIgnace Naert

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