Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing

ACS Omega
Yueyuan ZhengYou-Nian Liu

Abstract

Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network. The obtained blend hydrogel demonstrates remarkable shear-thinning and self-recovering properties. For antibacterial purpose, tannic acid was incorporated into the blend hydrogel. In addition, tannic acid-loaded blend hydrogel was verified to accelerate the wound healing on the mice model, significantly than the control groups. Thus, this paper presents a facile approach without chemical modification to construct injectable gelatin-based hydrogels, which have great potential as a wound dressing or tissue scaffold at body temperature.

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Citations

Oct 26, 2018·Biomaterials Science·Chengwei WangChangsheng Liu
Jun 4, 2020·Pharmaceutics·Atanu Naskar, Kwang-Sun Kim
Aug 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Namitha K PremanRenjith P Johnson
Jun 5, 2020·Journal of Tissue Engineering and Regenerative Medicine·Richun LiuXiao Chen
Jan 17, 2021·International Journal of Biological Macromolecules·K NgeceP Kumar
Apr 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenhu GuoLingyun Zhao
Jul 17, 2021·International Journal of Biological Macromolecules·Murugan Prasathkumar, Subramaniam Sadhasivam
Aug 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brinta BhattacharjeeJayanta Haldar
Jan 3, 2022·International Journal of Pharmaceutics·Gizem Cigdem DemirAyşen Tezcaner

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Methods Mentioned

BETA
chemical modification
scanning electron microscopy
Rheology
rheometry

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