Gelatin-based membrane containing usnic acid-loaded liposomes: A new treatment strategy for corneal healing.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Flavia Rodrigues da SilvaP S Nunes

Abstract

To evaluate the safety and potential healing efficacy of the topical ocular administration of a gelatin membrane containing usnic acid/liposomes (UALs) for corneal cicatrization. UALs have shown healing activity in animal models of dermal burn lesions. We evaluated the safety of topical ocular administration of UAL and its potential healing efficacy as an ophthalmic treatment on chemical lesions in rabbit eyes. The Draize test was used to check for ocular toxicity and the score was zero at each observation, indicating the ocular safety of a gelatin membrane containing usnic acid/liposome. Its potential healing efficacy as an ophthalmic treatment on chemical lesions in rabbit eyes was also assessed. After epithelial removal and treatment with UAL, there was a 49.4 % reduction in injury under in vivo conditions compared with a 36.6 % reduction in the control, a gelatin membrane containing liposome without usnic acid. Histological analysis of ocular surface chemical injury-tissue sections after treatment with UAL supported these observations. The corneal expression of VEGF and TGF-β1increased by 70 % and 50 % respectively following treatment with UAL gelatin membrane. These results indicate the potential therapeutic application of...Continue Reading

References

Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K Spanel-Borowski
Feb 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N P Luepke
Sep 1, 1984·Survey of Ophthalmology·J W Shell
Apr 16, 1998·Progress in Retinal and Eye Research·C L BourlaisR Leverge
Dec 23, 1998·Survey of Ophthalmology·P LeeA P Adamis
Jul 14, 2001·Fitoterapia·C S VijayakumarE Sukumar
Sep 5, 2002·Journal of Biomedical Materials Research·T I ValdesF Moussy
Apr 9, 2004·Laboratory Animals·B HowardM Ritskes-Hoitinga
Apr 27, 2004·Experimental Eye Research·Keith M Meek, Craig Boote
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
Nov 26, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Bradley K McCollMarc G Achen
Mar 24, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thórdís KristmundsdóttirKristín Ingólfsdóttir
Sep 24, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Joseph MichaelsGeoffrey C Gurtner
Feb 6, 2008·Emergency Medicine Clinics of North America·Jordan Spector, William G Fernandez
Nov 26, 2008·The Journal of Surgical Research·Philip BaoHarold Brem
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Mar 14, 2009·The Journal of Investigative Dermatology·Harold BremMarjana Tomic-Canic
Jul 7, 2009·Burns : Journal of the International Society for Burn Injuries·Flávia S L GomesCarlos E Salas
Jan 2, 2010·Emergency Nurse : the Journal of the RCN Accident and Emergency Nursing Association·Zena Rodrigues
Feb 10, 2010·Planta medica·Eydis EinarsdóttirHelga M Ogmundsdóttir
Feb 22, 2011·Journal of Cataract and Refractive Surgery·Derek W DelMonte, Terry Kim
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Jun 15, 2011·Arquivos brasileiros de oftalmologia·Glauco Henrique Reggiani MelloHamilton Moreira
Jul 16, 2011·Lasers in Surgery and Medicine·Ying WangMin Yao
Oct 18, 2011·Investigative Ophthalmology & Visual Science·Qihua LeJianjiang Xu
May 30, 2012·Current Drug Delivery·Gemma VilarFernando Albericio
Feb 26, 2013·Bioorganic & Medicinal Chemistry·Michela BrunoLuisella Verotta
Aug 21, 2013·Journal of Dermatological Science·Nicholas S GreavesArdeshir Bayat
Nov 30, 2013·Pharmacology & Therapeutics·Michael J Giese, Robert C Speth
Dec 6, 2014·International Journal of Biological Macromolecules·Jennifer BiscaratCeline Pochat-Bohatier
May 24, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Diamantis AlmaliotisVasileios Karampatakis
Jul 22, 2015·Progress in Retinal and Eye Research·Alexander V Ljubimov, Mehrnoosh Saghizadeh
Jul 24, 2015·Drug Development and Industrial Pharmacy·Angela FabianoYlenia Zambito
Sep 1, 2015·Advances in Colloid and Interface Science·Samuel GauseAnuj Chauhan

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Citations

Nov 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lays Fernanda Nunes DouradoArmando Silva-Cunha
Feb 5, 2021·Advanced Drug Delivery Reviews·S G AntimisiarisS Mourtas
Jul 31, 2021·Journal of Biomaterials Science. Polymer Edition·Samuel Ogbeide Ebhodaghe

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