Gelatin nanoencapsulation of protein/peptide drugs using an emulsifier-free emulsion method

Journal of Microencapsulation
J K LiX S Wu

Abstract

The nanoencapsulation of a model protein drug, bovine serum albumin (BSA), using gelatin as the matrix material is reported. Nanoencapsulation was conducted using a modified water-in-oil (w/o) emulsion method, which is emulsifier-free and simple. The nanoencapsulation product, BSA-containing gelatin nanoparticles, is characterized in terms of nanoparticle morphology, size and size distribution, water content, and in vitro protein release. The BSA-containing gelatin nanoparticles obtained from this nanoencapsulation process are nearly spherical and have a log-normal size distribution. The average diameter of the BSA-containing gelatin nanoparticles is approximately 840 nm. They can absorb 51-72% of water. In vitro release experiments demonstrate that BSA has been successfully encapsulated in, and can be released from the gelatin nanoparticles. The release of BSA from the gelatin nanoparticulate matrix follows a diffusion-controlled release mechanism. It is found that temperature affects both the water content and the BSA release rate of the gelatin nanoparticles.

References

Jan 1, 1992·Journal of Pharmaceutical Sciences·M M Welz, C M Ofner
May 1, 1989·Pharmaceutical Research·Y Tabata, Y Ikada
Sep 1, 1987·The Journal of Pharmacy and Pharmacology·Y Tabata, Y Ikada
Feb 1, 1986·Pharmaceutical Research·W Sadée

❮ Previous
Next ❯

Citations

Oct 16, 2013·Colloids and Surfaces. B, Biointerfaces·Jina Susan VargheseNishter Nishad Fathima
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Isabella SchöllErika Jensen-Jarolim
Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·J K LiX S Wu
Feb 13, 2001·International Journal of Pharmaceutics·H Fan, A K Dash
Jun 17, 2003·Journal of Biomaterials Science. Polymer Edition·Wen-Hsiang ChangHsing-Wen Sung
May 7, 2015·Expert Opinion on Drug Delivery·Maytal Foox, Meital Zilberman
Oct 26, 2011·Journal of Drug Targeting·Carla G MoutinhoVictor M Balcão
Dec 20, 2012·Journal of Drug Targeting·Jitendra KawadkarMeenakshi Kanwar Chauhan
Jan 9, 2015·Pharmaceutical Development and Technology·Rania M Hathout, Mohamed K Omran
Oct 13, 2009·International Journal of Pharmaceutics·Gaurav Kant SaraogiG P Agrawal
Dec 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aleksandra M UrbanskaSatya Prakash
Sep 29, 2009·Colloids and Surfaces. B, Biointerfaces·Avnesh KumariSubhash C Yadav
Aug 19, 2015·International Journal of Biological Macromolecules·Nityananda SahooKetousetuo Kuotsu
May 27, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Manoj NaharNarendra Kumar Jain
Apr 12, 2008·Biomaterials·Sepideh Heydarkhan-HagvallWilliam R MacLellan
Apr 15, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mei LinPiotr Tomasik
Jan 9, 2013·Critical Reviews in Biotechnology·David Hudson, Argyrios Margaritis
Oct 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O Elzoghby
Apr 10, 2002·Journal of Biomaterials Applications·Kezban UlubayramNesrin Hasirci
Nov 29, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Teresa RussoLuigi Ambrosio
May 8, 2003·Journal of Biomedical Materials Research. Part a·Huang-Chien LiangHsing-Wen Sung
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yanzhong ZhangZheng-Ming Huang
Jan 10, 2003·Journal of Biomaterials Science. Polymer Edition·Kezban UlubayramNesrin Hasirci
Jun 30, 2007·Journal of Biomedical Materials Research. Part a·Ximing XuMyron Spector
Apr 9, 2008·Journal of Environmental Monitoring : JEM·William Hannah, Paul B Thompson
Jul 28, 2010·Chemistry : a European Journal·Anitha Ethirajan, Katharina Landfester
Nov 7, 2019·Current Drug Delivery·Sunil Kumar DubeyShailendra Saraf
Jan 17, 2016·Macromolecular Bioscience·Kambiz FarbodSander C G Leeuwenburgh
Feb 26, 2010·Science and Technology of Advanced Materials·Sushmitha SundarSubhas C Kundu
Jul 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Milad FathiDavid Julian McClements
Jul 30, 2020·International Journal of Biological Macromolecules·Adarsha H J GowdaAbhay Pandit
Aug 1, 2008·Biomacromolecules·Anitha EthirajanKatharina Landfester
Mar 10, 2015·International Journal of Biological Macromolecules·P R Sarika, Nirmala Rachel James
Dec 10, 2018·ACS Biomaterials Science & Engineering·Annish JainSonia Kapoor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.