Gelatin nanoparticles enhance the neuroprotective effects of intranasally administered osteopontin in rat ischemic stroke model

Drug Delivery and Translational Research
Elizabeth JoachimHyungsoo Choi

Abstract

As a leading cause of death and adult disability, ischemic stroke requires the development of non-invasive, long-acting treatments. Osteopontin (OPN) is an endogenous protein shown to have neuroprotective effects in the post-ischemic brain of rats when administered through the non-invasive, intranasal pathway. Previously, gelatin microspheres (GMSs) have been shown to enhance the neuroprotective effects of OPN when used as a carrier during instrastriatal administration, but GMSs are generally too large to enter the brain parenchyma following intranasal administration. Here, gelatin nanoparticles (GNPs) were investigated as a carrier for intranasal delivery of an OPN peptide for the treatment of ischemic stroke. We not only successfully fabricated GNPs with a uniform shape, but also demonstrated the ability of these GNPs to pass into the brain parenchyma following intranasal administration. Critically, the use of GNPs as a carrier allowed for a 71.57 % reduction in mean infarct volume and extended the therapeutic window of intranasally administered OPN peptide to at least 6 h post-middle cerebral artery occlusion (MCAO). Our findings support the development of GNPs as a promising drug delivery platform for the intranasal treatme...Continue Reading

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Citations

Jan 15, 2016·Advanced Drug Delivery Reviews·Andrew J Sawyer, Themis R Kyriakides
Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Mar 8, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Il-Doo KimJa-Kyeong Lee
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Nov 14, 2019·Neural Regeneration Research·Rocío Fernandez-SerraDaniel González-Nieto
Aug 11, 2019·Colloids and Surfaces. B, Biointerfaces·Mohaddeseh Mahmoudi Saber
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Jun 27, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Elizabeth JoachimHyungsoo Choi
Apr 1, 2021·Neurochemistry International·Buket Ucar

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