Gelatinase B in proliferative vitreoretinal disorders

American Journal of Ophthalmology
Ahmed M Abu El-AsrarGhislain Opdenakker

Abstract

To investigate whether gelatinases A and B are involved in the pathogenesis of proliferative vitreoretinal disorders. In a prospective study of 101 consecutive patients, vitreous and paired serum samples were obtained from 38 patients with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy, 25 patients with rhegmatogenous retinal detachment with no proliferative vitreoretinopathy, and 38 patients with proliferative diabetic retinopathy. Gelatinase activities were determined by quantitative zymography. All vitreous samples contained comparable levels of the constitutive gelatinase A. Inducible gelatinase B was detected in eight (32%) of 25 vitreous samples from patients with rhegmatogenous retinal detachment with no proliferative vitreoretinopathy (mean +/- SD, 319.5 +/- 521.0 scanning units), in 17 (44.7%) of 38 vitreous samples from patients with proliferative vitreoretinopathy (560.6 +/- 718.9 scanning units), and in 34 (89.5%) of 38 vitreous samples from patients with proliferative diabetic retinopathy (1,707.2 +/- 1,220.3 scanning units). The incidence of detection of gelatinase B in proliferative diabetic retinopathy cases was significantly higher than it was in rhegmatogenous retinal detachme...Continue Reading

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Citations

Nov 13, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sirpa LoukovaaraJorma Keski-Oja
Oct 26, 2000·The British Journal of Ophthalmology·J L AshworthD McLeod
Mar 22, 2007·International Ophthalmology·Ahmed M Abu El-AsrarKarel Geboes
Aug 31, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chrysanthos SymeonidisStavros A Dimitrakos
Sep 15, 2007·Journal of Neurochemistry·Andrea M PappGábor Juhász
Apr 29, 2006·Experimental Eye Research·Francis J DescampsAhmed M Abu El-Asrar
Apr 4, 2013·Critical Reviews in Biochemistry and Molecular Biology·Jennifer VandoorenGhislain Opdenakker
May 5, 2001·Expert Opinion on Pharmacotherapy·R P DanisL Pratt
Jan 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francis J DescampsGhislain Opdenakker
Nov 13, 2003·Expert Opinion on Emerging Drugs·Matthew A SpeicherLinda Pratt
Jan 28, 2009·Survey of Ophthalmology·Neelakshi BhagatMarco A Zarbin

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