Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis

Immunobiology
Elzbieta KolaczkowskaB Arnold

Abstract

Murine zymosan-induced peritonitis represents a well-defined model of acute inflammation. However, the molecular mechanisms by which leukocytes degrade basement membranes during extravasation into the peritoneum are not clear. Gelatinase B (MMP-9) is thought to participate in cellular migration, yet its role in leukocyte transmigration through endothelia during inflammation remains controversial. The aim of the present study was to evaluate the role of MMP-9 in the cell influx during zymosan-induced experimental peritonitis. In zymosan-treated Balb/c mice MMP-9 and its natural inhibitor (tissue inhibitor of metalloproteinase 1 - TIMP-1) were present in the peritoneal fluid and plasma at the time of peritoneal neutrophil (polymorphonuclear leukocyte - PMN) infiltration and persisted there until the time of monocytes/macrophages influx. To probe the function of gelatinases, gelatinase B-deficient mice (MMP-9(-/-)) were used as well as Balb/c mice treated with cyclic CTTHWGFTLC (INH), a specific peptide inhibitor of gelatinases. The studies revealed that in either group of mice deprived of MMP-9 activity, PMN infiltration was impaired at the time of their maximal extravasation (6h) while tumor necrosis factor alpha (TNF-alpha), cy...Continue Reading

References

Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·G Murphy, A J Docherty
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H E Van Wart, H Birkedal-Hansen
Jul 1, 1987·Chest·E J CampbellH G Welgus
Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·N S DohertyA J Milici
Mar 1, 1994·Immunology Today·G Opdenakker, J Van Damme
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M ShipleyS D Shapiro
Feb 20, 1998·Journal of Leukocyte Biology·M N AjueborM Perretti
May 13, 1998·Immunology Today·G OpdenakkerJ Van Damme
Aug 4, 1998·The Journal of Experimental Medicine·Z LiuR M Senior
Sep 28, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·L O NelimarkkaH T Järveläinen
May 26, 1999·American Journal of Respiratory Cell and Molecular Biology·T BetsuyakuR M Senior
Aug 3, 1999·Nature Biotechnology·E KoivunenR Pasqualini
Mar 10, 2000·Biochimica Et Biophysica Acta·K BrewH Nagase
Mar 30, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I Nagaoka, S Hirota
Aug 5, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A D'HaeseG Opdenakker
Sep 15, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E KolaczkowskaB Plytycz
Sep 28, 2001·Trends in Immunology·G OpdenakkerJ Van Damme
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Jan 24, 2003·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E Kolaczkowska
Jan 24, 2003·Critical Reviews in Biochemistry and Molecular Biology·Philippe E Van den SteenGhislain Opdenakker
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca E YoungSussan Nourshargh
Aug 3, 2004·Nature Reviews. Immunology·William C ParksYolanda S López-Boado

❮ Previous
Next ❯

Citations

Oct 2, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J L Hoover-PlowE Hart
Jun 2, 2007·Nature Reviews. Drug Discovery·Jialiang HuGhislain Opdenakker
Aug 9, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G P L ThomasW A Morrison
Mar 29, 2008·Molecular Pharmacology·Nadine DraginDaniel W Nebert
Mar 8, 2011·Journal of Biomaterials Science. Polymer Edition·A Scislowska-CzarneckaE Kolaczkowska
Nov 4, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Elzbieta KolaczkowskaBernd Arnold
Dec 3, 2014·Pharmacology & Therapeutics·Chengxue QinRebecca H Ritchie
Sep 4, 2012·Tissue & Cell·A Scislowska-CzarneckaE Kolaczkowska
Jun 30, 2009·Journal of Molecular and Cellular Cardiology·Rogelio Zamilpa, Merry L Lindsey
Jun 7, 2008·The American Journal of Pathology·Hendrik W van DeventerJonathan S Serody
Jan 11, 2008·Journal of Biomedical Materials Research. Part a·Elzbieta PamulaMagdalena Chadzinska
Sep 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takashi HamadaAna J Coito
Sep 29, 2011·European Journal of Immunology·Christel VérolletIsabelle Maridonneau-Parini
Feb 24, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Abdirisak Ahmed Haji OmarJaana Hagström
Jul 12, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabrina R PerriJacques Galipeau
Dec 12, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jian SongLydia M Sorokin
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Meenakshi MalikTimothy J Sellati
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Senad DivanovicDaniel W Nebert
Feb 23, 2020·Pharmaceutics·Laia Gifre-RenomElena Garcia-Fruitós
Jul 14, 2020·ACS Omega·Geetha VenkatachalamMukesh Doble

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.