Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Clinical Hemorheology and Microcirculation
E HoppsG Caimi

Abstract

Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation and then in the development and progression of cardiovascular diseases. Our aim was to evaluate plasma levels of gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in a group of subjects with OSAS. We enrolled 48 subjects (36 men and 12 women; mean age 49.7 ± 14.68 yrs) with OSAS diagnosed with a 1-night cardiorespiratory study and then we subdivided these subjects into two subgroups according to the apnea/hypopnea index (AHI): Low (L = 21 subjects with AHI <30) and High (H = 27 subjects with AHI >30). We measured plasma concentration of the gelatinases and their inhibitors using ELISA kits. We observed a significant increase in plasma concentration of MMP-9, MMP-2, TIMP-1 and TIMP-2 in the entire group of OSAS subjects and in the two subgroups, with higher levels in the H in comparison with the L subgroup. In the whole group of OSAS subjects we also noted a significant decrease in MMP-9/TIMP-1 ratio in comparison with normal controls. Only MMP-9 was significantly correlated with the severity of...Continue Reading

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Citations

Oct 21, 2015·Clinical Hemorheology and Microcirculation·Gregorio CaimiEugenia Hopps
Oct 8, 2015·Clinical Hemorheology and Microcirculation·Jing KangLifang Xu
Oct 3, 2020·Sleep & Breathing = Schlaf & Atmung·Aleksandra FranczakGrzegorz Sawicki
Aug 23, 2020·International Journal of Molecular Sciences·Megan K DeBari, Rosalyn D Abbott
Oct 28, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Saif MashaqiSairam Parthasarathy
Dec 4, 2021·Frontiers in Physiology·Jolanda H M van BilsenLars Verschuren

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