Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineering

Acta Biomaterialia
Huaping TanChangyou Gao

Abstract

Poly(lactide-co-glycotide) (PLGA) microspheres integrated into gelatin/chitosan/hyaluronan scaffolds were fabricated by freeze-drying and crosslinking with 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide. The effects of the microspheres on porosity, density, compressive modulus, phosphate-buffered saline uptake ratio and weight loss of the scaffolds were evaluated. Generally, a scaffold with a higher PLGA content had a lower porosity and weight loss, and a medium uptake ratio, but a larger apparent density and compressive modulus. When the PLGA content was lower than 50%, the PLGA-integrated scaffolds had a similar pore size (approximately 200microm) as that of the control, and as much as 90% of their porosity could be preserved. In vitro chondrocyte culture in the 50% PLGA-integrated scaffold demonstrated that the cells could proliferate and secrete extracellular matrix at the same level as in the control gelatin/chitosan/hyaluronan scaffold.

References

Oct 1, 1988·Analytical Biochemistry·Y J KimA J Grodzinsky
Jan 1, 1993·Journal of Biomedical Materials Research·L E FreedR Langer
May 16, 1998·Plastic and Reconstructive Surgery·C D SimsM J Yaremchuk
Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J L ClelandA Cuthbertson
Jun 28, 2001·Journal of Biomedical Materials Research·G S DasT Chandy
Feb 21, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G A AmeerR Langer
Dec 31, 2002·Biomaterials·Jin Shu MaoKang De Yao
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sung Eun KimIck Chan Kwon
Sep 24, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wanyao XiaYilin Cao
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Robert O CookIan W Kellaway
May 26, 2005·Biomaterials·Yi HongJiacong Shen
Jul 12, 2005·Biomaterials·Yan HuangSundararajan V Madihally
Nov 10, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·N ShanmugasundaramMary Babu
Jan 5, 2006·Journal of Biomedical Materials Research. Part a·Diederik H R KempenMichael J Yaszemski
Apr 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu S ZolnikDiane J Burgess
May 18, 2006·International Journal of Pediatric Otorhinolaryngology·Andrea Ciorba, Alessandro Martini
May 30, 2006·Journal of Biomechanics·Ivan MartinDavid Wendt
Jun 22, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Francesca UngaroMaria Immacolata La Rotonda
Apr 26, 2007·Macromolecular Bioscience·Jose F Alvarez-Barreto, Vassilios I Sikavitsas
May 24, 2007·Tissue Engineering·Antonios G MikosGordana Vunjak-Novakovic
Jun 8, 2007·Journal of Materials Science. Materials in Medicine·Huaping TanChangyou Gao

❮ Previous
Next ❯

Citations

Jul 18, 2012·Bioprocess and Biosystems Engineering·Cristian A AcevedoJavier Enrione
Feb 3, 2011·Journal of Materials Science. Materials in Medicine·Xifu ZhengQuanyi Guo
Jun 18, 2011·Journal of Materials Science. Materials in Medicine·Lihong LaoChangyou Gao
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Fereshteh MirahmadiShahin Bonakdar
Apr 27, 2011·Tissue Engineering. Part C, Methods·Clara R CorreiaJoão F Mano
Jun 23, 2010·Journal of Biomaterials Science. Polymer Edition·Z Seden AkdemirSabriye Karadenizli
Apr 28, 2011·Biomicrofluidics·Koyal Garg, Gary L Bowlin
Oct 19, 2011·Journal of Biomedicine & Biotechnology·Seogjin Seo, Kun Na
Jul 21, 2012·Artificial Cells, Nanomedicine, and Biotechnology·Mehlika Pulat, Gulen Oytun Akalin
Mar 14, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Mehlika PulatNilay Demirkol Karahan
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·A ThiemR Zehbe
Aug 21, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yanhong WenHanne Mørck Nielsen
Dec 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aleksandra M UrbanskaSatya Prakash
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jingxuan YanXiaohong Hu
Oct 29, 2011·Journal of Tissue Engineering and Regenerative Medicine·Hsiang-Jung TsengShan-Hui Hsu
Apr 15, 2014·Journal of Tissue Engineering and Regenerative Medicine·Fang HuangYa-Dong Dong
Jul 1, 2012·Carbohydrate Polymers·Riccardo A A MuzzarelliAntonio Gigante
Nov 8, 2014·Bioprocess and Biosystems Engineering·Cristian A AcevedoDonald I Brown
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Farnaz GhorbaniAli Zamanian
Jul 9, 2016·International Journal of Biological Macromolecules·Atif IslamMuhammad Hamid Raza
Mar 11, 2011·Biomacromolecules·S Van VlierbergheE Schacht
Jun 21, 2012·Experimental Biology and Medicine·Ramar Perumal SamyFrank Watt
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Huinan ChenXiaohong Hu
Mar 26, 2016·Stem Cells Translational Medicine·Bruna CorradettiEnnio Tasciotti
May 28, 2017·International Journal of Biological Macromolecules·Annalisa La GattaChiara Schiraldi
Jun 18, 2017·Regenerative Medicine·Khushboo GulatiKrishna Mohan Poluri
Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Piergiorgio GentileZebunnissa Ramtoola
Jan 14, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Parinita AgrawalPradeep Kumar Patra
Jan 17, 2019·Tissue Engineering. Part B, Reviews·Mohsen SetayeshmehrMohammad T Joghataei
Oct 27, 2011·Expert Review of Medical Devices·Junmin Zhu, Roger E Marchant
Sep 4, 2012·Macromolecular Rapid Communications·Huaping TanDangsheng Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.