Gelatinous marrow transformation and hematopoietic atrophy in a miniature horse stallion

Veterinary Pathology
J Beeler-MarfisiD Bienzle

Abstract

Gelatinous marrow transformation, or serous atrophy of bone marrow fat, has been noted in livestock, laboratory animals, and wildlife in association with an inadequate plane of nutrition, inanition, or intoxication. This is a report of gelatinous marrow transformation and hematopoietic marrow atrophy in a 5-year-old miniature horse stallion. The horse had oral malformations leading to poor food assimilation and emaciation. A bone marrow biopsy obtained to investigate persistent anemia and leukopenia showed hematopoietic atrophy and replacement of fat with a granular extracellular substance, which stained with alcian blue, consistent with acidic mucopolysaccharide content. Surgical correction of the dental abnormalities resulted in improved food assimilation, weight gain, and resolution of cytopenias. In humans, gelatinous bone marrow transformation and hematopoietic atrophy are commonly associated with malnutrition from anorexia nervosa and other causes. The cause of hematopoietic atrophy is unknown but may relate to a nonsupportive marrow microenvironment and inadequate hematopoietic substrate availability. Similar pathogenic mechanisms were suspected in this horse.

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Citations

Mar 17, 2015·European Radiology·Robert D BoutinMiriam A Bredella
Mar 24, 2020·Veterinary Clinical Pathology·Mackenzie E LongJessica A Hokamp
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Javier AsínFrancisco A Uzal

Methods Mentioned

BETA
biopsy

Related Concepts

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Anemia

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Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

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