Gelatinous marrow transformation and hematopoietic atrophy in a miniature horse stallion

Veterinary Pathology
J Beeler-MarfisiD Bienzle


Gelatinous marrow transformation, or serous atrophy of bone marrow fat, has been noted in livestock, laboratory animals, and wildlife in association with an inadequate plane of nutrition, inanition, or intoxication. This is a report of gelatinous marrow transformation and hematopoietic marrow atrophy in a 5-year-old miniature horse stallion. The horse had oral malformations leading to poor food assimilation and emaciation. A bone marrow biopsy obtained to investigate persistent anemia and leukopenia showed hematopoietic atrophy and replacement of fat with a granular extracellular substance, which stained with alcian blue, consistent with acidic mucopolysaccharide content. Surgical correction of the dental abnormalities resulted in improved food assimilation, weight gain, and resolution of cytopenias. In humans, gelatinous bone marrow transformation and hematopoietic atrophy are commonly associated with malnutrition from anorexia nervosa and other causes. The cause of hematopoietic atrophy is unknown but may relate to a nonsupportive marrow microenvironment and inadequate hematopoietic substrate availability. Similar pathogenic mechanisms were suspected in this horse.


Apr 1, 1976·Scandinavian Journal of Haematology·M TavassoliH Finkel
Sep 1, 1986·American Journal of Hematology·B H BjornsonA I Tauber
Apr 1, 1983·Equine Veterinary Journal·P LeesJ B Taylor
Jan 1, 1980·Acta Medica Scandinavica·D E AnderssonA Ost
Jun 1, 1995·American Journal of Hematology·P S Mehler, S E Howe
May 1, 1997·The International Journal of Eating Disorders·M LambertJ P Devogelaer
Aug 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W LinR Stern
Jan 13, 2000·The American Journal of Surgical Pathology·J Böhm
Apr 1, 2000·The International Journal of Eating Disorders·E OrlandiG P Guaraldi
May 23, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Peter Bollen, Mikala Skydsgaard
Oct 2, 2007·Acta Veterinaria Scandinavica·Terje D JosefsenKathrine A Ryeng
Sep 24, 2008·Journal of Leukocyte Biology·Daniele FocosiMario Petrini
Oct 16, 2008·Annals of Biomedical Engineering·Umut Atakan Gurkan, Ozan Akkus
Nov 5, 2008·American Journal of Veterinary Research·Rebecca S McConnicoRustin M Moore
Dec 2, 2008·The International Journal of Eating Disorders·Gero HütterWolf-K Hofmann


Mar 17, 2015·European Radiology·Robert D BoutinMiriam A Bredella
Mar 24, 2020·Veterinary Clinical Pathology·Mackenzie E LongJessica A Hokamp
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Javier AsínFrancisco A Uzal

Methods Mentioned


Related Concepts

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Related Papers

Veterinary Clinical Pathology
D J Weiss, Michael Henson
Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
D W ScruggsA W Groce
© 2021 Meta ULC. All rights reserved