Gelation and micellization behaviors of pluronic(®) F127 hydrogel containing poly(isobutylcyanoacrylate) nanoparticles specifically designed for mucosal application

Colloids and Surfaces. B, Biointerfaces
Bénédicte PradinesKawthar Bouchemal

Abstract

The aim of this investigation is to combine the advantages of pluronic(®) F127 hydrogels and nanoparticles composed of poly(isobutylcyanoacrylate) (PIBCA) core coated with a mixture of chitosan and thiolated chitosan to design novel multifunctional formulation for mucosal application. Nanoparticles offer the advantage of being mucoadhesive while pluronic(®) F127 hydrogel allowed prolonged contact time onto mucosal surfaces. This work highlights an unprecedented comprehensive study on the effect of nanoparticles on gelation and micellization behaviors of pluronic(®) F127 using rheology and micro-calorimetry experiments. Results showed that presence of nanoparticles induced (i) smaller crystal peak of F127, (ii) a decrease of the enthalpy of F127 micellization and (iii) a non-reversibility of micelle formation (during heating ramp) and micelle melting (during cooling ramp). Together, these findings suggest that a part of F127 was not able to associate into micelles and the formation of mixed micelles containing F127 unimers and PIBCA/(chitosan/thiolated chitosan) copolymer and/or PIBCA homopolymer was suspected. The interaction of F127 unimers with nanoparticles resulted from their physical de-structuration as revealed by nanopar...Continue Reading

References

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Citations

May 26, 2017·Clinical Microbiology Reviews·Kawthar BouchemalPhilippe M Loiseau
Oct 28, 2019·Lab on a Chip·Chong ShenQin Meng
Jan 7, 2017·Biotechnology Advances·Monika HospodiukIbrahim T Ozbolat
Nov 13, 2019·ACS Infectious Diseases·Sophia MalliKawthar Bouchemal

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