PMID: 11336386May 5, 2001Paper

Gellan film as an implant for insulin delivery

Journal of Biomaterials Applications
J LiC Dwivedi

Abstract

Gellan gum is an anionic polysaccharide produced by the aerobic fermentation of Pseudomonas elodea in batch culture. Gellan undergoes calcium-induced cross-linking to form a three-dimensional network, and this property makes it particularly attractive for the incorporation of biological moieties such as proteins. In this study, a procedure for the preparation of gellan films was developed and optimized, and the characteristics of these films were investigated. In addition, the effects of the concentration of each ingredient in gellan films and in vitro release behavior of fluorescein isothiocyanate dextran from these films was examined. This film device was implanted for insulin delivery in diabetic rats. The blood glucose levels of the diabetic rats implanted with insulin-loaded films were about half of those implanted with blank films, and this therapeutic effect of insulin could last for one week. Both in vitro and in vivo studies indicated that the gellan film could be an ideal candidate in the development of protein delivery systems.

References

Jan 1, 1990·Biotechnology & Genetic Engineering Reviews·M Mackay
Apr 1, 1990·European Journal of Drug Metabolism and Pharmacokinetics·L M Sanders
Dec 1, 1993·The Journal of Pharmacy and Pharmacology·J P Bai, L L Chang

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Citations

May 29, 2008·Applied Microbiology and Biotechnology·Arsenio M FialhoIsabel Sá-Correia
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Silvia SuriniKozo Takayama
May 13, 2014·Carbohydrate Polymers·Priya VashisthVikas Pruthi
Mar 2, 2005·Drug Delivery·J BalasubramaniamShri Kant
Dec 3, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Junwu XiaoFangfang Xu
Aug 8, 2013·Critical Reviews in Biotechnology·S V N Vijayendra, T R Shamala
Dec 3, 2016·Drug Development and Industrial Pharmacy·Duangkamon Sakloetsakun, Thaned Pongjanyakul
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thangavelu MuthukumarGilson Khang
Feb 14, 2021·Polymers·Masrina Mohd NadzirMinh Hong Nguyen

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