Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans

Fitoterapia
You-Kai XuHuai-Rong Luo

Abstract

Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectroscopic (for both) and single-crystal X-ray diffraction (for 1) analysis. All compounds isolated were evaluated for their potential as immunosuppressive agents and the data suggested that Gelsemium alkaloids of different structural types possibly have potential as immunosuppressive agents.

Citations

Mar 20, 2014·BMC Complementary and Alternative Medicine·Marta MarzottoPaolo Bellavite
Sep 8, 2015·Fitoterapia·Hong-Ru WuYing Zhu
Sep 18, 2015·Frontiers in Plant Science·Ibrahim JantanSyed Nasir Abbas Bukhari
Jun 24, 2015·Journal of Natural Products·You-Kai XuPing Zhang
Dec 3, 2014·Fitoterapia·Jing-Yang Zhang, Yong-Xiang Wang
May 27, 2020·Rapid Communications in Mass Spectrometry : RCM·Zi-Yuan WangZhao-Ying Liu
Feb 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meng-Ting ZuoZhao-Ying Liu

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