Gemcitabine and cisplatin in refractory malignant lymphoma

Oncology
Agustín AvilésRaúl Fernández

Abstract

We performed a pilot study to evaluate the effect of the high-dose gemcitabine-cisplatin combination in a brief weekly regimen in the treatment of primary refractory diffuse large cell lymphoma with high or high-intermediate clinical risk. Thirty patients refractory to first-line anthracycline-based chemotherapy were treated with a combination of gemcitabine (1.5 g/m(2) i.v.) and cisplatin (50 mg/m(2) i.v.) on days 1, 8, 22, 29, 42 and 49. No further treatment was administered. Complete response rate was 53%; and only two relapses have been observed at the last follow-up. Thus actuarial disease-free survival at the 3-year follow-up was: 87% (95% confidence interval, CI: 70-93%) and overall survival 53% (95% CI: 44-63%). Toxicity was mild, and treatment was well tolerated. No treatment-related death was observed. The gemcitabine-cisplatin combination appears to be promising in the treatment of refractory lymphoma patients, with a low toxicity. However, a longer follow-up is needed to confirm the results. In our opinion, prolonged chemotherapy (6-8 cycles) did not improve outcome. At present, we are testing if the use of monoclonal antibodies (anti-CD20) employed as maintenance therapy may improve disease-free survival and overal...Continue Reading

Citations

Jul 16, 2011·Cancer Chemotherapy and Pharmacology·John L ReaganAnthony E Mega
Oct 26, 2013·Annals of Hematology·Eliza A HawkesIan Chau
Mar 10, 2016·Asia-Pacific Journal of Clinical Oncology·Jae-Cheol JoUNKNOWN CoOperative Study Group A for Hematology (COSAH)
Apr 8, 2010·Clinical Lymphoma, Myeloma & Leukemia·Agustin AvilésMaría de Jesús Nambo
Feb 16, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tara SeshadriArmand Keating
Jul 31, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A AvilésL Silva

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