Gemcitabine and oxaliplatin followed by paclitaxel and carboplatin as first line therapy for patients with suboptimally debulked, advanced epithelial ovarian cancer. A phase II trial of sequential doublets. The GO-First Study

Gynecologic Oncology
C B SteerP G Harper

Abstract

Gemcitabine and oxaliplatin are active in epithelial ovarian cancer with minimal overlapping toxicity. We studied the efficacy and toxicity of this combination in patients with advanced ovarian cancer when given prior to carboplatin and paclitaxel. Chemonaive patients with epithelial ovarian cancer and measurable disease were eligible for the study. Treatment consisted of gemcitabine 1250 mg/m2 on days 1 and 8 and oxaliplatin 130 mg/m2 on day 8 every 21 days (GO) for 4 cycles. This was followed by carboplatin AUC = 6 and paclitaxel 175 mg/m2 on day 1 every 21 days (CP) for 4 cycles. Twenty patients, median age 62 years (range 39-78), FIGO stages III (16) and IV (4) received treatment. The response rate (RR) after 4 cycles of GO was 80% (95%CI 61-99%) (4 complete responses (CR), 12 partial responses (PR)). Interval debulking surgery was performed in 7 patients (35%). After CP chemotherapy, RR increased to 85% (95%CI 68-100%) (CR = 13, PR = 4). Median time to progression was 14.5 months. Estimated median overall survival was 31.5 months. Toxicities of GO were mild; grade 3/4 nausea in 3 patients (15%) and vomiting in 2 patients (10%), grade 3/4 neutropenia in 5 patients (25%). Grade 2/3 peripheral neuropathy occurred in 5 patient...Continue Reading

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Citations

May 1, 2007·Women's Health·Fadi Abushahin, Peter G Rose
Jan 14, 2009·Molecular Cancer Therapeutics·Sarah R McWhinneyHoward L McLeod
Oct 1, 2013·International Journal of Molecular Sciences·Hongwei YueGuangju Chen
Aug 10, 2013·Journal of Experimental & Clinical Cancer Research : CR·Patrizia ViciLuigi Di Lauro
May 31, 2016·Journal of the Egyptian National Cancer Institute·Mohamed Elshebeiny, Walid Almorsy
Dec 3, 2008·Blood Reviews·Moya S CunninghamJames S O'Donnell
May 17, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lesley J Fallowfield, Peter Harper
Jul 17, 2019·Biomarkers in Cancer·Ruchika PokhriyalGururao Hariprasad

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