Gemcitabine-induced thrombotic microangiopathy with nephrotic syndrome

CEN Case Reports
Daisuke Katagiri, Fumihiko Hinoshita

Abstract

We encountered a case of gemcitabine (GEM)-induced secondary thrombotic microangiopathy (TMA) with nephrotic syndrome. Advanced pancreatic cancer with liver metastasis had originally been diagnosed. Renal biopsy showed focal reduplication of the glomerular basement membrane, endothelial cell swelling, and narrowed capillary lumens with fragmented erythrocytes and fibrin deposition, compatible with TMA. Regular monitoring of renal function during GEM treatment and discontinuation of treatment if acute kidney injury (AKI) might occur is crucial, because AKI combined with TMA is life-threatening.

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Citations

Jul 15, 2020·Journal of the American Society of Nephrology : JASN·Purva SharmaUNKNOWN Northwell Nephrology COVID-19 Research Consortium
Jun 10, 2021·SAGE Open Medical Case Reports·Mohammed Ali Madkhali
Jul 20, 2021·Drug Metabolism Letters·Carmen E CervantesMohamed G Atta

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