Gemcitabine-loaded DSPE-PEG-PheoA liposome as a photomediated immune modulator for cholangiocarcinoma treatment

Biomaterials
Da Hye KimKun Na

Abstract

To improve the therapeutic efficacy of gemcitabine (GEM) as an anticancer drug for bile duct cancer, GEM-loaded liposomes (GDPPL) prepared from a photosensitizer-conjugated lipid were investigated regarding the drug release kinetics, photodynamic therapy (PDT) efficacy, and immunomodulatory effects. The release rate of GEM from the liposomes was improved approximately 2-fold compared to non-laser irradiation groups due to lipid disruption by reactive oxygen species produced from the activated photosensitizer upon laser irradiation. Through in vitro testing using a human liver bile duct carcinoma cell line (HuCCT-1), the cytotoxicity of GDPPL with laser irradiation was enhanced due to rapid GEM release and PDT effects. Furthermore, the results of in vivo tests using a HuCCT-1 tumor-bearing xenograft mice model showed that GDPPL exhibited approximately 3-fold antitumoral effects compared to control group. Additionally, immunohistochemical analysis demonstrated the recruitment of immunostimulatory cells in tumor tissues. IHC tests in BALB/c mice indicated that GDPPL under laser irradiation dramatically enhanced the quantities of various immune cells for effective antitumoral immunotherapy against biliary tract cancer. From these r...Continue Reading

Citations

Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wenhai LinGang Han
Jul 25, 2019·Biomaterials·Sanjana GhoshJonathan F Lovell
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhaohai PanDefang Li
Apr 24, 2021·Chemistry and Physics of Lipids·Pedro Henrique Correia de LimaRenato Márcio Ribeiro-Viana
May 15, 2020·Molecular Pharmaceutics·Da Hye KimKun Na
Sep 4, 2021·Advanced Drug Delivery Reviews·Hayoon JeongKun Na
Nov 6, 2020·International Journal of Pharmaceutics·Shweta ParohaPrashant Kesharwani

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