Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases.

Journal of Neuro-oncology
Singh AvninderC Sarkar

Abstract

Gemistocytic astrocytomas (GAs) are a distinct variant of astrocytomas, generally classified as WHO grade II, and are associated with an aggressive biological behavior. This study was undertaken to determine the histomorphological spectrum, and correlate these with their proliferative potential and genetic alterations, in order to establish a biological basis for their unfavorable prognosis.A total of 32 GAs diagnosed during an 11-year period (1993-2003) were included in the study. Immunoreactivity for CD3 (T-cells), CD20 (B-cells) and CD68 (macrophages) were evaluated to characterize the perivascular inflammatory infiltrates, while p53, epidermal growth factor receptor (EGFR), cyclin D1 and p27-immunolabeling were studied to analyze the tumor biology.Overall, the mean gemistocytic index in the study was 39.6% (range, 12.2-80.8%), with multinucleation in gemistocytes and mitosis being present in 56.2% and 15.6% respectively. Perivascular mononuclear cell cuffing was seen in 56.2% cases, which was immunopositive for CD3 and CD68 in 14 cases each, with 13 cases being immunopositive for both. Similar type of inflammatory infiltrates was also present within the tumor parenchyma. Proliferation index depicted by MIB-1 LI was low (mea...Continue Reading

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Citations

Apr 2, 2019·Scientific Reports·Bernadeta MasiulionytėDaina Skiriutė
Sep 30, 2008·Medical Oncology·Abdul-Zaher M KhattabWaleed A Essa
Aug 12, 2014·AJNR. American Journal of Neuroradiology·A LasockiF Gaillard
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May 13, 2010·Journal of Neuro-oncology·Georgia LevidouPenelope Korkolopoulou
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May 17, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yosef LavivShlomit Yust-Katz

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