Abstract
Gemistocytic astrocytomas (GAs) are a distinct variant of astrocytomas, generally classified as WHO grade II, and are associated with an aggressive biological behavior. This study was undertaken to determine the histomorphological spectrum, and correlate these with their proliferative potential and genetic alterations, in order to establish a biological basis for their unfavorable prognosis.A total of 32 GAs diagnosed during an 11-year period (1993-2003) were included in the study. Immunoreactivity for CD3 (T-cells), CD20 (B-cells) and CD68 (macrophages) were evaluated to characterize the perivascular inflammatory infiltrates, while p53, epidermal growth factor receptor (EGFR), cyclin D1 and p27-immunolabeling were studied to analyze the tumor biology.Overall, the mean gemistocytic index in the study was 39.6% (range, 12.2-80.8%), with multinucleation in gemistocytes and mitosis being present in 56.2% and 15.6% respectively. Perivascular mononuclear cell cuffing was seen in 56.2% cases, which was immunopositive for CD3 and CD68 in 14 cases each, with 13 cases being immunopositive for both. Similar type of inflammatory infiltrates was also present within the tumor parenchyma. Proliferation index depicted by MIB-1 LI was low (mea...Continue Reading
References
May 1, 1975·Journal of Neuropathology and Experimental Neurology·T HoshinoW G Ellis
Mar 1, 1991·Journal of Neurosurgery·H G KrouwerM Prados
Jan 1, 1990·Acta Neuropathologica·W PaulusW Roggendorf
Mar 1, 1988·Journal of Neurosurgery·E R Hitchcock, C S Morris
Mar 1, 1988·Journal of Neurosurgery·S MiescherV von Fliedner
Jan 1, 1987·Acta Neuropathologica·M L RossiD B Brownell
May 1, 1988·Journal of Neuropathology and Experimental Neurology·S H BignerD D Bigner
Jan 1, 1994·Journal of Neuropathology and Experimental Neurology·D N Louis
Jan 1, 1996·Acta neurochirurgica·B GiomettoB Tavolato
Sep 1, 1996·Acta Neuropathologica·W RoggendorfW Paulus
Nov 19, 1997·Neuroscience Letters·R PivaD Schiffer
Mar 14, 1998·Acta Neuropathologica·P CavallaD Schiffer
Jul 3, 1998·Acta Neuropathologica·K WatanabeH Ohgaki
May 18, 2001·Acta Neuropathologica·T TamiyaT Ohmoto
Nov 9, 2001·Acta Neuropathologica·R M ReisH Ohgaki
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Paul KleihuesWebster K Cavenee
Jan 28, 2003·Cancer·Ruut M KirlaEeva K Salminen
Dec 10, 2003·Acta neurochirurgica·H J YangD G Kim
Citations
Apr 2, 2019·Scientific Reports·Bernadeta MasiulionytėDaina Skiriutė
Sep 11, 2009·Blood·Isabelle I SallesHans Deckmyn
Jun 23, 2020·Nuclear Medicine Communications·Nisha RaniAnil K Mishra
May 15, 2013·Journal of Neurosurgery·Ranjith BabuCory Adamson
Sep 30, 2008·Medical Oncology·Abdul-Zaher M KhattabWaleed A Essa
Aug 12, 2014·AJNR. American Journal of Neuroradiology·A LasockiF Gaillard
Aug 17, 2020·Nuclear Medicine Communications·Nisha RaniAnil K Mishra
Feb 9, 2019·Frontiers in Molecular Neuroscience·Luca SalaMarialuisa Lavitrano
May 13, 2010·Journal of Neuro-oncology·Georgia LevidouPenelope Korkolopoulou
Sep 25, 2015·Current Opinion in Neurology·Michał Bieńkowski, Matthias Preusser
Jul 31, 2018·Arkhiv patologii·D E MatskoE N Imyanitov
May 23, 2007·Archives of Pathology & Laboratory Medicine·C Ryan Miller, Arie Perry
May 17, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yosef LavivShlomit Yust-Katz
May 3, 2008·Pathology, Research and Practice·Roberto TiraboscoStefano Pizzolitto