GenABEL: an R library for genome-wide association analysis

Bioinformatics
Yurii S AulchenkoCornelia M van Duijn

Abstract

Here we describe an R library for genome-wide association (GWA) analysis. It implements effective storage and handling of GWA data, fast procedures for genetic data quality control, testing of association of single nucleotide polymorphisms with binary or quantitative traits, visualization of results and also provides easy interfaces to standard statistical and graphical procedures implemented in base R and special R libraries for genetic analysis. We evaluated GenABEL using one simulated and two real data sets. We conclude that GenABEL enables the analysis of GWA data on desktop computers. http://cran.r-project.org.

References

Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
May 23, 2006·Trends in Genetics : TIG·David M Evans, Lon R Cardon

❮ Previous
Next ❯

Citations

Mar 8, 2011·Archives of Toxicology·Klaus GolkaJan G Hengstler
Jun 24, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Marie-Capucine DupuisMichel Georges
Nov 5, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Laura J CorbinMark Vaudin
Dec 8, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hille FietenJan Rothuizen
Apr 14, 2011·Molecular Genetics and Genomics : MGG·Ozren PolašekIgor Rudan
Dec 18, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Tara E SeeryJason A Zell
Jun 19, 2010·Journal of Cardiovascular Translational Research·Guillaume Pare
Sep 5, 2012·European Journal of Drug Metabolism and Pharmacokinetics·Nilufer RahmiogluKourosh R Ahmadi
May 1, 2013·The British Journal of Nutrition·Toby AndrewKourosh R Ahmadi
Aug 4, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Thomas EspesethIvar Reinvang
Jan 20, 2012·Journal of Proteome Research·Radka SaldovaPauline M Rudd
Jun 19, 2009·European Journal of Human Genetics : EJHG·Uljana A BoyarskikhMaxim L Filipenko
Feb 16, 2012·European Journal of Human Genetics : EJHG·Wen-Hua WeiChris S Haley
Nov 17, 2010·Molecular Psychiatry·K WangUNKNOWN Price Foundation Collaborative Group
Jun 23, 2010·Molecular Psychiatry·A DemirkanC M Middeldorp
Jun 19, 2012·Nature Genetics·Xiang Zhou, Matthew Stephens
Sep 4, 2012·Nature Genetics·Elin GrundbergUNKNOWN Multiple Tissue Human Expression Resource (MuTHER) Consortium
Sep 18, 2012·Nature Genetics·Gulnara R SvishchevaYurii S Aulchenko
Dec 4, 2012·Nature Genetics·Momoko HorikoshiUNKNOWN Early Growth Genetics (EGG) Consortium
Dec 9, 2008·Nature Genetics·Yurii S AulchenkoUNKNOWN ENGAGE Consortium
Oct 6, 2009·Nature Genetics·Fernando RivadeneiraUNKNOWN Genetic Factors for Osteoporosis (GEFOS) Consortium
Apr 13, 2010·Nature Genetics·Anna KöttgenCaroline S Fox
May 11, 2010·Nature Genetics·Clare TurnbullDouglas F Easton
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Dec 28, 2010·Nature Genetics·UNKNOWN GoDARTS and UKPDS Diabetes Pharmacogenetics Study GroupEwan R Pearson
Jul 12, 2011·Nature Genetics·Zsofia Kote-JaraiUNKNOWN PRACTICAL Consortium
Nov 19, 2010·Nature Protocols·Carl A AndersonKrina T Zondervan
Apr 10, 2008·Nature Reviews. Genetics·Mark I McCarthyJoel N Hirschhorn
May 10, 2013·Nature Reviews. Genetics·Evangelos Evangelou, John P A Ioannidis
Jan 1, 2011·Translational Psychiatry·P MerjonenT Lehtimäki
Oct 4, 2012·Translational Psychiatry·M L McDonaldR L Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.