Gender- and age-related differences in muscular and nerve-mediated responses in human colon.

Digestive Diseases and Sciences
M A MaselliFabrizio De Ponti

Abstract

Gender- and age-related differences in muscular and nerve-mediated responses in human colon are poorly characterized. We studied carbachol-induced motor responses and electrically evoked contractions in sigmoid circular muscle from adult and elderly patients of different gender. Sigmoid colon segments were obtained from 24 men and 16 women undergoing left hemicolectomy for colon cancer. Isometric tension was measured on muscle strips exposed to increasing carbachol concentrations. The effects of atropine, guanethidine, L-nitro arginine methyl ester (L-NAME), and tetrodotoxin on electrically evoked contractions were also studied. Female patients showed higher maximal response to carbachol than male patients, elderly females being the most sensitive to carbachol among all patient groups. Electrically evoked contractions were linearly related to stimulation frequency and abolished by tetrodotoxin. Electrically evoked contractions were significantly more pronounced in elderly male patients; they were reduced by atropine and guanethidine and increased by L-nitro arginine methyl ester in the presence of atropine and guanethidine (P < 0.05). The effect of L-NAME was most marked in elderly male patients and least pronounced in elderly ...Continue Reading

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Citations

Nov 28, 2013·European Journal of Pharmacology·Maria Antonietta MaselliMaria Grazia Perrone
Sep 6, 2012·British Journal of Pharmacology·G J SangerC H Knowles
Jun 8, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A MaselliC Severi
Aug 5, 2018·BMC Pharmacology & Toxicology·Maria Antonietta MaselliCarola Severi

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