Gender affects renal vasoconstrictor response to Ang I and Ang II

Hypertension
S K GandhiN J Brown

Abstract

This study tested the hypothesis that gender affects the pressor and renal vasoconstrictor responses to angiotensin (Ang) I and Ang II in salt-replete normotensive subjects. Ang I and Ang II were infused in graded doses into 9 men and 8 women in a randomized, single-blind, crossover study. There were no differences between genders in baseline blood pressure, heart rate, sodium excretion, renal plasma flow, angiotensin-converting enzyme (ACE) genotype, ACE activity, plasma renin activity, aldosterone, or Ang II levels. Although pressor responses to Ang I and Ang II were similar in men and women, there was a negative relationship between the change in mean arterial pressure and the change in heart rate during Ang I and II infusion in women only. The half-time of the pressor response after discontinuation of Ang I but not Ang II infusion was greater in men than in women (9.5+/-2.2 versus 4.3+/-2.1 minutes, P<.05). This difference in duration did not result from gender differences in the metabolism of Ang I because Ang II levels measured during Ang I infusion were identical in men and women. In contrast, the renal vasoconstrictor response to Ang I and Ang II was significantly increased in women compared with that in men (Ang I, -24...Continue Reading

References

Dec 1, 1992·Hypertension·G H WilliamsN K Hollenberg
Feb 14, 1992·Biochemical and Biophysical Research Communications·N Iwai, T Inagami
Nov 1, 1991·Hypertension·C M FerrarioE A Tallant
Sep 1, 1985·Cardiovascular Research·P J MaceW A Littler
Apr 1, 1967·The Journal of Clinical Endocrinology and Metabolism·L C Chesley, I H Tepper
Nov 1, 1973·The Journal of Clinical Investigation·N F GantP C MacDonald
Dec 1, 1984·Journal of Hypertension·B G ZimmermanP C Wong
Jul 1, 1982·The American Journal of Physiology·I A ReidL C Keil
Dec 1, 1983·The Journal of Clinical Investigation·D M ShobackN K Hollenberg
Jun 1, 1980·The Journal of Clinical Endocrinology and Metabolism·S L SwartzT J Moore
Mar 16, 1995·The New England Journal of Medicine·K LindpaintnerC H Hennekens
Jul 23, 1993·Regulatory Peptides·B BunnemannD Ganten
Aug 1, 1961·American Journal of Obstetrics and Gynecology·R ABDUL-KARIM, S ASSALIN
Mar 15, 1965·American Journal of Obstetrics and Gynecology·L C CHESLEYF P ZUSPAN

❮ Previous
Next ❯

Citations

Sep 11, 1998·Journal of Cardiovascular Pharmacology·N J BrownA Adam
Feb 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Afsana MomenLawrence I Sinoway
Jun 25, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Markus P SchneiderDavid M Pollock
Mar 31, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Manisha GupteLisa A Cassis
Oct 2, 2004·Kidney International·Todd S PerlsteinNaomi D L Fisher
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gert Mayer
Apr 26, 2016·Advanced Biomedical Research·Aghdas DehghaniMehdi Nematbakhsh
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Analia Lorena Tomat, Francisco Javier Salazar
Dec 20, 2007·American Journal of Hypertension·Vincent J CanzanelloArlene B Chapman
Oct 19, 2017·Journal of Cardiovascular Pharmacology·Jazmin Flores-MonroyLuisa Martínez-Aguilar
Apr 23, 1999·Pharmacotherapy·D A Sica, N K Hollenberg
Nov 4, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Armando Reyes-EngelCarlos Maria Ferrario
Sep 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anna E StanhewiczNina S Stachenfeld
Jan 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Baojian XueMeredith Hay
Mar 16, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sameed AhmedAnita T Layton
Feb 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer C Sullivan
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Pascale H Lane
Jan 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaya PamidimukkalaMeredith Hay
Oct 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Baojian XueAlan Kim Johnson
May 18, 2005·Canadian Journal of Physiology and Pharmacology·R Tatchum-TalomD S Martin
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jane F Reckelhoff, J Carlos Romero
Aug 5, 2000·Journal of Applied Physiology·D E WatenpaughP Norsk
May 11, 2013·Molecular Biology Reports·Negar FirouzabadiMassoumeh Shafiei
Nov 18, 2011·American Journal of Physiology. Renal Physiology·David D M NichollSofia B Ahmed
Oct 26, 2012·American Journal of Physiology. Renal Physiology·Virginia ReverteF Javier Salazar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.