Gender-affirming hormone treatment and cognitive function in transgender young adults: a systematic review and meta-analysis.

Psychoneuroendocrinology
Maria A KaralexiFotios C Papadopoulos

Abstract

Previous studies have examined whether steroid hormone treatment in transgender individuals may affect cognitive function; yet, their limited power does not allow firm conclusions to be drawn. We leveraged data from to-date literature aiming to explore the effect of gender-affirming hormone administration on cognitive function in transgender individuals. A search strategy of MEDLINE was developed (through June 1, 2019) using the key terms transgender, hormone therapy and cognitive function. Eligible were (i) cohort studies examining the longitudinal effect of hormone therapy on cognition, and (ii) cross-sectional studies comparing the cognitive function between treated and non-treated individuals. Standardized mean differences (Hedges' g) were pooled using random-effects models. Study quality was evaluated using the Newcastle-Ottawa Scale. Ten studies (seven cohort and three cross-sectional) were eligible representing 234 birth-assigned males (aM) and 150 birth-assigned females (aF). The synthesis of cohort studies (n = 5) for visuospatial ability following hormone treatment showed a statistically significant enhancement among aF (g = 0.55, 95% confidence intervals [CI]: 0.29, 0.82) and an improvement with a trend towards stati...Continue Reading

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Citations

Sep 25, 2020·Journal of Nursing Management·Francisco Montes-GaldeanoMiguel Rodriguez-Arrastia
Jun 3, 2021·European Journal of Sport Science·Blair R HamiltonYannis Pitsiladis
Sep 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Michele A O'ConnellKen C Pang

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