Gender and age specific differences in exhaled isoprene levels

Respiratory Physiology & Neurobiology
Matthias LechnerJosef Rieder

Abstract

The analysis of volatile organic compounds (VOC) in the human breath has attracted a considerable amount of clinical and scientific interest during the last decade. In our study, we turned our attention to gender and age specific differences of exhaled volatile compounds, particularly on isoprene which is one of the most abundant organic molecules found in human exhaled air. A total of 126 test persons were enrolled in the study: 66 females and 60 males. Moreover, the participants were classified into six groups with regard to their age. In a standardized setting all of them had to exhale the endexpiratory breath into a sample bag. The volatile compounds at m/z values from 21 to 229 were analyzed by using proton-transfer-reaction-mass-spectrometry. Isoprene (at m/z 69) was found to be highly significantly (p<0.001) elevated in the exhaled air of male subjects. Furthermore, it could be shown that 19-29 years old subjects exhale significantly lower levels of isoprene than older adults (p=0.002). No significant differences between groups were detected for any other measured mass. In conclusion, the present study demonstrates gender and age specific differences of isoprene levels in the exhaled air. These findings may be of potenti...Continue Reading

References

Jun 30, 1987·Toxicology and Applied Pharmacology·A R DahlR F Henderson
Sep 17, 1984·Biochemical and Biophysical Research Communications·E S DenerisJ F Mead
Aug 1, 1995·Free Radical Research·S MendisD E Euler
Feb 1, 1995·Current Microbiology·J KuzmaR Fall
Sep 1, 1993·Journal of Clinical Pathology·M PhillipsJ Greenberg
Nov 1, 1995·Free Radical Biology & Medicine·S MendisD E Euler
Oct 28, 1996·Toxicology·R D Taalman
Jan 1, 1997·Rapid Communications in Mass Spectrometry : RCM·J TaucherW Lindinger
Jun 3, 1999·Journal of the Air & Waste Management Association·J D Fenske, S E Paulson
Apr 9, 2001·The European Respiratory Journal·L T McGrathS Elborn
May 5, 2001·Annual Review of Plant Physiology and Plant Molecular Biology·Thomas D Sharkey, Sansun Yeh
Jun 9, 2001·Chemico-biological Interactions·W P WatsonB T Golding
Aug 21, 2001·European Journal of Heart Failure·L T McGrathB Silke
Sep 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Joachim ScholppKlaus Geiger
May 20, 2003·The Breast Journal·Michael PhillipsCynthia Wong
Jun 11, 2003·Chest·Michael PhillipsWilliam N Rom

❮ Previous
Next ❯

Citations

Jun 25, 2014·Metabolites·Célia Lourenço, Claire Turner
Nov 15, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E van MastrigtM W Pijnenburg
Oct 12, 2017·Journal of Breath Research·Sean W HarshmanJennifer A Martin
Jan 22, 2019·Indoor Air·Magdalena Kruza, Nicola Carslaw
Dec 23, 2017·The European Respiratory Journal·Kevin LamoteJan P van Meerbeeck
Apr 23, 2011·Journal of Breath Research·David SmithGordon A A Ferns
Nov 16, 2012·Journal of Breath Research·Cyrill HornussGustav Schelling
Jan 24, 2020·Journal of Breath Research·Dieuwke van DartelCecile de Vos
Apr 10, 2020·Journal of Breath Research·Mitchell M McCartneyCristina E Davis
Oct 7, 2015·Oncotarget·Agne KrilaviciuteHermann Brenner
Oct 23, 2020·Journal of Breath Research·B T AndrewsG Hancock
Mar 18, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Alma NietoVíctor R De Jesús
Feb 14, 2009·Chemical Reviews·Robert S BlakeAndrew M Ellis
Aug 15, 2017·The Journal of Infection·Rosarito Coronel TeixeiraCecile Magis-Escurra
Dec 10, 2020·Environmental Science & Technology·Nijing WangJonathan Williams
Sep 26, 2014·Analytical Chemistry·Alexander A AksenovCristina E Davis
Jan 22, 2020·Environmental Science & Technology·Chloe BirenVíctor R De Jesús

❮ Previous
Next ❯

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